Elucidating the Relationship Between Acetazolamide Plasma Protein Binding and Renal Clearance Using an Albumin Infusion

1992 ◽  
Vol 32 (11) ◽  
pp. 1028-1032 ◽  
Author(s):  
Irving H. Gomolin ◽  
Dennis J. Chapron
Keyword(s):  
Protein Binding ◽  
Renal Clearance ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Albumin Infusion ◽  
The Relationship

The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester

Life Sciences ◽  
1982 ◽  
Vol 30 (15) ◽  
pp. 1271-1279 ◽  
Author(s):  
Hazel H. Szeto ◽  
Jason G. Umans ◽  
Hilary R. Umans ◽  
Jeffrey W. McFarland
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Third Trimester ◽  
Fetal Plasma ◽  
The Third ◽  
The Relationship

Renal clearance and plasma protein binding of oxytetracycline in man

1960 ◽  
Vol 15 (1) ◽  
pp. 106-108 ◽  
Author(s):  
S. A. Kaplan ◽  
A. M. Yuceoglu ◽  
J. Strauss
Keyword(s):  
Protein Binding ◽  
Renal Clearance ◽  
Human Plasma ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Technical Assistance ◽  
Tubular Secretion ◽  
Renal Tubular Secretion ◽  
Renal Tubular

The clearance of oxytetracycline was measured in eight children, four of whom also received glucosamine. The average clearance of oxytetracycline was 163.7 ml/min./1.73 m2 in the eight experiments and the average clearance of inulin was 115.8 ml/min/1.73 m2. About two-thirds of the oxytetracycline appearing in the urine was filtered at the glomeruli. One-third was secreted by the tubules. About three-fourths of the oxytetracycline in human plasma was found to be dialyzable and one-fourth bound to protein. Glucosamine (40 mg/kg) administered for 24 hours did not significantly modify the renal tubular secretion of oxytetracycline. Note: (With Technical Assistance by S. Graziano and R. Kanter) Submitted on April 22, 1959

scholarly journals Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data

2017 ◽  
Vol 69 (1) ◽  
pp. 175-179
Author(s):  
Jadranka Odovic ◽  
Jovana Trbojevic ◽  
Jasna Trbojevic-Stankovic ◽  
Dejan Nesic ◽  
Ratomir Jelic
Keyword(s):  
Linear Regression ◽  
Protein Binding ◽  
Calcium Channel ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Calcium Channel Blockers ◽  
Molecular Descriptors ◽  
Molecular Properties ◽  
Channel Blockers ◽  
The Relationship

In this study we investigated the relationship between the calcium channel blockers (CCBs), amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem, and their calculated molecular descriptors: polar surface area (PSA), molecular weight (Mw), volume value (Vol), aqueous solubility data (logS), lipophilicity (logP), acidity (pKa values) and plasma protein binding (PPB) data, obtained from relevant literature. The relationships between the computed molecular properties of selected CCBs and their PPB data were investigated by simple linear regression analysis that revealed very low correlations (R2<0.35). When multiple linear regression (MLR) analysis was applied to investigate reliable correlations between the CCBs? calculated molecular descriptors and PPB data, the best correlations were found for the relationships between CCBs, and PPB data and lipophilicity, and with application of the molecular descriptor (Mw, Vol, or pKa) data as additional independent variables (R2=0.623; R2=0.741; R2=0.657, respectively), with an acceptable probability value (P<0.05), confirming that lipophilicity, together with other molecular properties, are essential for the drugs? PPB. We conclude that this could be considered as an additional in vitro approach for modeling CCBs.

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