Severity of Cirrhosis and the Relationship of ??1-Acid Glycoprotein Concentration to Plasma Protein Binding of Lidocaine

1990 ◽  
Vol 34 (6) ◽  
pp. 399
Author(s):  
M. BERRY ◽  
P. W. N. KEELING ◽  
D. WEIR ◽  
J. FEELY
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Acid Glycoprotein ◽  
Relationship Of ◽  
The Relationship

The relationship between maternal and fetal plasma protein binding of methadone in the ewe during the third trimester

Life Sciences ◽  
1982 ◽  
Vol 30 (15) ◽  
pp. 1271-1279 ◽  
Author(s):  
Hazel H. Szeto ◽  
Jason G. Umans ◽  
Hilary R. Umans ◽  
Jeffrey W. McFarland
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Third Trimester ◽  
Fetal Plasma ◽  
The Third ◽  
The Relationship

Selective plasma protein binding of antimalarial drugs to α1-acid glycoprotein

2008 ◽  
Vol 16 (7) ◽  
pp. 3759-3772 ◽  
Author(s):  
Ferenc Zsila ◽  
Júlia Visy ◽  
György Mády ◽  
Ilona Fitos
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Antimalarial Drugs ◽  
Acid Glycoprotein

scholarly journals Characterization of Binding of Raltegravir to Plasma Proteins

2013 ◽  
Vol 57 (10) ◽  
pp. 5147-5150 ◽  
Author(s):  
Caroline Barau ◽  
Valérie Furlan ◽  
Yazdan Yazdanpanah ◽  
Catherine Fagard ◽  
Jean-Michel Molina ◽  
...  
Keyword(s):  
Protein Binding ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Plasma Proteins ◽  
Association Constant ◽  
Graphical Method ◽  
Acid Glycoprotein ◽  
Ph Increase

ABSTRACTThe objective of this study was to characterize raltegravir (RAL) binding to albumin and alpha-1-acid glycoprotein (AAG). Unbound and bound RAL were separated by ultrafiltration. The association constant (Ka) was estimated by a graphical method. In HIV-infected patients, the average plasma protein binding is 76%. RAL did not bind to AAG but bound to nonsaturable, low-affinity albumin sites with ann(number of sites) ·Kaproduct of 9.8 × 102liters/mol. A pH increase of 0.2 U led to a 2% increase in the bound fraction.

scholarly journals Assessment of the relationship between the molecular properties of calcium channel blockers and plasma protein binding data

2017 ◽  
Vol 69 (1) ◽  
pp. 175-179
Author(s):  
Jadranka Odovic ◽  
Jovana Trbojevic ◽  
Jasna Trbojevic-Stankovic ◽  
Dejan Nesic ◽  
Ratomir Jelic
Keyword(s):  
Linear Regression ◽  
Protein Binding ◽  
Calcium Channel ◽  
Plasma Protein Binding ◽  
Plasma Protein ◽  
Calcium Channel Blockers ◽  
Molecular Descriptors ◽  
Molecular Properties ◽  
Channel Blockers ◽  
The Relationship

In this study we investigated the relationship between the calcium channel blockers (CCBs), amlodipine, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil and diltiazem, and their calculated molecular descriptors: polar surface area (PSA), molecular weight (Mw), volume value (Vol), aqueous solubility data (logS), lipophilicity (logP), acidity (pKa values) and plasma protein binding (PPB) data, obtained from relevant literature. The relationships between the computed molecular properties of selected CCBs and their PPB data were investigated by simple linear regression analysis that revealed very low correlations (R2<0.35). When multiple linear regression (MLR) analysis was applied to investigate reliable correlations between the CCBs? calculated molecular descriptors and PPB data, the best correlations were found for the relationships between CCBs, and PPB data and lipophilicity, and with application of the molecular descriptor (Mw, Vol, or pKa) data as additional independent variables (R2=0.623; R2=0.741; R2=0.657, respectively), with an acceptable probability value (P<0.05), confirming that lipophilicity, together with other molecular properties, are essential for the drugs? PPB. We conclude that this could be considered as an additional in vitro approach for modeling CCBs.

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