Aim. The use of modern information technologies makes it possible to achieve a qualitatively new level of control in supply chains. In these conditions, ensuring information security is the most important task. The article shows the possibilities of applying the spatial concepts of the actor-network theory in the interests of forming a relevant intelligent information security management system for supply chains. Materials and methods. The article discusses a new approach based on the provisions of the actor-network theory, which makes it possible to form the structure of an intelligent information security control system for supply chains, consisting of three main functional blocks: technical, psychological and administrative. The incoming information security threats and the relevant system responses generated through the interaction of the system blocks were considered as enacting the three Law’s spaces: the space of regions, the space of networks and the space of fl uids. Results. It is shown that the stability of this system in the space of networks is a necessary condition for its successful functioning in the space of regions, and its resilience in the space of fl uids gained through the dynamic knowledge formation helps overcome the adverse effects of the fl uidity. The problems of the intentional / unintentional nature of information security threats, as well as the reactivity / proactivity of the corresponding responses of the intelligent information security management system for supply chains are investigated. Conclusions. The proposed approach showed the possibility of using such an interdisciplinary tool in the fi eld of information security as the concepts of the actor-network theory. The intelligent information security control system built on its basis ensures that almost all the features of solving information security problems in supply chains are taken into account.