scholarly journals Non‐clinical safety evaluation of repeated intramuscular administration of the AS15 immunostimulant combined with various antigens in rabbits and cynomolgus monkeys

2015 ◽  
Vol 36 (2) ◽  
pp. 238-256 ◽  
Author(s):  
N. Garçon ◽  
J. Silvano ◽  
C. F. Kuper ◽  
N. Baudson ◽  
C. Gérard ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Intramuscular Administration ◽  
Clinical Safety ◽  
Cynomolgus Monkeys

scholarly journals Non‐clinical safety evaluation of single and repeated intramuscular administrations of MAGE‐A3 Cancer Immunotherapeutic in rabbits and cynomolgus monkeys

2014 ◽  
Vol 35 (7) ◽  
pp. 717-728 ◽  
Author(s):  
Eric Destexhe ◽  
Emilie Grosdidier ◽  
Nathalie Baudson ◽  
Roy Forster ◽  
Catherine Gerard ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Clinical Safety ◽  
Cynomolgus Monkeys ◽  
Cancer Immunotherapeutic

Non-Clinical Safety Evaluation and Adverse Events in Phase I Trials

2007 ◽  
pp. 75-84
Author(s):  
Patricia M. Reed ◽  
Stuart J. Mair ◽  
Stephen Freestone
Keyword(s):  
Adverse Events ◽  
Phase I ◽  
Safety Evaluation ◽  
Phase I Trials ◽  
Clinical Safety

Enzymology in Preclinical Safety Evaluation

1992 ◽  
Vol 20 (3-2) ◽  
pp. 501-505 ◽  
Author(s):  
Dai T. Davies
Keyword(s):  
Enzyme Activities ◽  
Drug Effect ◽  
Safety Evaluation ◽  
Diagnostic Information ◽  
Maximum Amount ◽  
Adverse Drug Effect ◽  
Short Paper ◽  
Clinical Safety ◽  
Blood Samples ◽  
Preclinical Safety

This short paper will briefly discuss the merits of determining plasma enzyme activities in pre-clinical safety evaluation. Emphasis is placed on the value of selecting the appropriate enzymes and collecting blood samples at the appropriate times during the study, so as to gain the maximum amount of diagnostic information. Examples of actual results will be cited to illustrate some of the points. These examples are drawn from the 2 commonly used toxicology species—the laboratory white rat and the beagle—and serve to demonstrate the importance of enzymology in monitoring the progress or resolution of an adverse drug effect.

Safety evaluation of chronic intrathecal administration of heparan N-sulfatase in juvenile cynomolgus monkeys

2011 ◽  
Vol 2 (3) ◽  
pp. 187-200 ◽  
Author(s):  
Richard W. Pfeifer ◽  
Brian R. Felice ◽  
Robert B. Boyd ◽  
Mark T. Butt ◽  
Juan A. Ruiz ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Intrathecal Administration ◽  
Cynomolgus Monkeys

Pre-Clinical Safety Evaluation of Antimicrobial Bioadhesive Vaginal Formulations

2016 ◽  
Vol 14 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Mohd A. Alam ◽  
Farhan J. Ahmad ◽  
Zeenat I. Khan ◽  
Roop K. Khar
Keyword(s):  
Safety Evaluation ◽  
Clinical Safety

Safety evaluation of ambulatory infusion in socialised cynomolgus monkeys

2012 ◽  
Vol 211 ◽  
pp. S148
Author(s):  
Jean-Paul Briffaux ◽  
Stéphane Baudet ◽  
François Bossu ◽  
Catherine Botteron ◽  
Nigel Pickersgill ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Cynomolgus Monkeys
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