Pre-Clinical Safety Evaluation of Antimicrobial Bioadhesive Vaginal Formulations

2016 ◽  
Vol 14 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Mohd A. Alam ◽  
Farhan J. Ahmad ◽  
Zeenat I. Khan ◽  
Roop K. Khar
Keyword(s):  
Safety Evaluation ◽  
Clinical Safety

Non-Clinical Safety Evaluation and Adverse Events in Phase I Trials

2007 ◽  
pp. 75-84
Author(s):  
Patricia M. Reed ◽  
Stuart J. Mair ◽  
Stephen Freestone
Keyword(s):  
Adverse Events ◽  
Phase I ◽  
Safety Evaluation ◽  
Phase I Trials ◽  
Clinical Safety

Enzymology in Preclinical Safety Evaluation

1992 ◽  
Vol 20 (3-2) ◽  
pp. 501-505 ◽  
Author(s):  
Dai T. Davies
Keyword(s):  
Enzyme Activities ◽  
Drug Effect ◽  
Safety Evaluation ◽  
Diagnostic Information ◽  
Maximum Amount ◽  
Adverse Drug Effect ◽  
Short Paper ◽  
Clinical Safety ◽  
Blood Samples ◽  
Preclinical Safety

This short paper will briefly discuss the merits of determining plasma enzyme activities in pre-clinical safety evaluation. Emphasis is placed on the value of selecting the appropriate enzymes and collecting blood samples at the appropriate times during the study, so as to gain the maximum amount of diagnostic information. Examples of actual results will be cited to illustrate some of the points. These examples are drawn from the 2 commonly used toxicology species—the laboratory white rat and the beagle—and serve to demonstrate the importance of enzymology in monitoring the progress or resolution of an adverse drug effect.

Pre-clinical safety evaluation of heat shock protein 65–MUC1 peptide fusion protein

2007 ◽  
Vol 49 (1) ◽  
pp. 63-74 ◽  
Author(s):  
Yan Huo ◽  
Bo Li ◽  
Yingqi Zhang ◽  
Sanlong Wang ◽  
Musheng Bao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Fusion Protein ◽  
Safety Evaluation ◽  
Clinical Safety ◽  
Heat Shock Protein 65

Pre-clinical safety evaluation of a cell based medicinal product (stem cell therapy)

2010 ◽  
Vol 196 ◽  
pp. S98-S99
Author(s):  
I. Andreini ◽  
S. Cinelli ◽  
S. Venturella ◽  
G. Oberto
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Medicinal Product ◽  
Stem Cell Therapy ◽  
Safety Evaluation ◽  
Clinical Safety ◽  
A Cell
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