Endocrine disrupting chemicals, 4-nonylphenol, bisphenol A and butyl benzyl phthalate, impair metabolism of estradiol in male and female rats as assessed by levels of 15α-hydroxyestrogens and catechol estrogens in urine

2017 ◽  
Vol 38 (5) ◽  
pp. 688-695 ◽  
Author(s):  
Madoka Nakagomi ◽  
Emako Suzuki ◽  
Yoshiaki Saito ◽  
Tetsuji Nagao
Keyword(s):  
Bisphenol A ◽  
Endocrine Disrupting Chemicals ◽  
Female Rats ◽  
Male And Female ◽  
Catechol Estrogens ◽  
Butyl Benzyl Phthalate ◽  
Male And Female Rats ◽  
Endocrine Disrupting

scholarly journals Effects of perinatal bisphenol A exposure during early development on radial arm maze behavior in adult male and female rats

2014 ◽  
Vol 42 ◽  
pp. 17-24 ◽  
Author(s):  
Renee N. Sadowski ◽  
Pul Park ◽  
Steven L. Neese ◽  
Duncan C. Ferguson ◽  
Susan L. Schantz ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Early Development ◽  
Adult Male ◽  
Female Rats ◽  
Radial Arm Maze ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats

2015 ◽  
Vol 69 ◽  
pp. 89-97 ◽  
Author(s):  
Rachel E. Bowman ◽  
Victoria Luine ◽  
Samantha Diaz Weinstein ◽  
Hameda Khandaker ◽  
Sarah DeWolf ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Adult Male ◽  
Dendritic Spine ◽  
Female Rats ◽  
Spine Density ◽  
Male And Female ◽  
Dendritic Spine Density ◽  
Male And Female Rats

scholarly journals Interaction of bisphenol A (BPA) and soy phytoestrogens on sexually dimorphic sociosexual behaviors in male and female rats

2016 ◽  
Vol 84 ◽  
pp. 121-126 ◽  
Author(s):  
Kimani D. Hicks ◽  
Alana W. Sullivan ◽  
Jinyan Cao ◽  
Emily Sluzas ◽  
Meghan Rebuli ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Female Rats ◽  
Sexually Dimorphic ◽  
Male And Female ◽  
Male And Female Rats

scholarly journals Low-dose effects of bisphenol A on early sexual development in male and female rats

Reproduction ◽  
2014 ◽  
Vol 147 (4) ◽  
pp. 477-487 ◽  
Author(s):  
Sofie Christiansen ◽  
Marta Axelstad ◽  
Julie Boberg ◽  
Anne Marie Vinggaard ◽  
Gitte Alsing Pedersen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Sexual Development ◽  
Low Dose ◽  
Dose Range ◽  
Daily Intake ◽  
Reproductive Organ ◽  
Female Rats ◽  
Male And Female ◽  
Male And Female Rats ◽  
Pregnancy And Lactation

Bisphenol A (BPA) is widely detected in human urine and blood. BPA has been reported to impair many endpoints for reproductive and neurological development; however, it is controversial whether BPA has effects in the microgram per kilogram dose range. The aim of the current study was to examine the influence of BPA on early sexual development in male and female rats at dose levels covering both regulatory no observed adverse effect levels (NOAELs) (5 and 50 mg/kg bw per day) as well as doses in the microgram per kilogram dose range (0.025 and 0.25 mg/kg bw per day). Time-mated Wistar rats (n=22) were gavaged during pregnancy and lactation from gestation day 7 to pup day 22 with 0, 0.025, 0.25, 5 or 50 mg/kg bw per day BPA. From 0.250 mg/kg and above, male anogenital distance (AGD) was significantly decreased, whereas decreased female AGD was seen from 0.025 mg/kg bw per day and above. Moreover, the incidence of nipple retention in males appeared to increase dose relatedly and the increase was statistically significant at 50 mg/kg per day. No significant changes in reproductive organ weights in the 16-day-old males and females and no signs of maternal toxicity were seen. The decreased AGD at birth in both sexes indicates effects on prenatal sexual development and provides new evidence of low-dose adverse effects of BPA in rats in the microgram per kilogram dose range. The NOAEL in this study is clearly below 5 mg/kg for BPA, which is used as the basis for establishment of the current tolerable daily intake (TDI) by EFSA; thus a reconsideration of the current TDI of BPA appears warranted.

scholarly journals Bisphenol a Hormonal Disrupture and Preventive Effect of Rose Water and Clove Oil

2020 ◽  
Vol 11 (2) ◽  
pp. 8780-8803
Keyword(s):  
Bisphenol A ◽  
Corn Oil ◽  
Histopathological Examination ◽  
Female Rats ◽  
Male Rats ◽  
Histopathological Analysis ◽  
Clove Oil ◽  
Male And Female ◽  
Male And Female Rats ◽  
Stimulating Hormone

Bisphenol A (BPA) which considered synthetic estrogen that is an essential component of many plastic industries. This research was done to see the impacts of exposure of BPA on reproductive organs and hormonal levels in male and female albino Sprague-Dawley rats. The protective effect of rose water and clove oil on BPA was investigated. Ninety rats were divided into 18 groups, 9 groups of males and they are like for females. Rats were exposed to different oral gavage route 3 times a week by doses of BPA (20 µg, 20 mg, 200 mg) /kg b.wt for 6 weeks and BPA was solubilized in corn oil. BPA induced a significant decrease in total and free testosterone in male rats, in contrast to a significant increase in thyroid-stimulating hormone (TSH), progesterone, estrogen (E2), and prolactin (PRL), while a decrease in Follicle-stimulating hormone (FSH) compared to control groups. Histopathological examination revealed that rosewater and clove oil reduced testes and ovary damages induced by BPA. Rosewater and clove oil components were scanned using GC/MS, which showed that rosewater and clove oil contains phenols, flavonoids, and these inevitably confirm that a prominent role in preventing the damage during treatment. Results indicated that the used doses of BPA disrupted the sex hormone levels in both male and female rats caused reproductive impaired. The chemical and histopathological analysis results indicated that clove oil and rose water improved the adverse effect of BPA. Rosewater and clove oil improved the changes which were stimulated by BPA.

scholarly journals Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

2017 ◽  
Author(s):  
Robin B. Gear ◽  
Scott M. Belcher
Keyword(s):  
Immune System ◽  
Bisphenol A ◽  
Ethinyl Estradiol ◽  
Endocrine Disrupting Chemicals ◽  
Wide Spread ◽  
Male And Female ◽  
Synthetic Chemicals ◽  
Endocrine Disrupting ◽  
The Impact

ABSTRACTThe endocrine disruptor bisphenol A (BPA) and the pharmaceutical 17α-ethinyl estradiol (EE) are synthetic chemicals with estrogen-like activities. Despite ubiquitous human exposure to BPA, and the wide-spread clinical use of EE as oral contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is unclear. Here we report results of in vivo dose response studies that analyzed the histology and microstructural changes in the spleen of adult male and female CD-1 mice exposed to 4 to 40,000 μg/kg/day BPA or 0.02 to 2 μg/kg/day EE from conception until 12-14 weeks of age. Results of that analysis indicate that both BPA and EE have dose- and sex-specific impacts on the cellular and microanatomical structures of the spleens that reveal minor alterations in immunomodulatory and hematopoietic functions. These findings support previous studies demonstrating the murine immune system as a sensitive target for estrogens, and that oral exposures to BPA and EE can have estrogen-like immunomodulatory affects in both sexes.

Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats

2002 ◽  
Vol 937 (1-2) ◽  
pp. 1-7 ◽  
Author(s):  
Anna Maria Aloisi ◽  
Daniele Della Seta ◽  
Carmela Rendo ◽  
Ilaria Ceccarelli ◽  
Andrea Scaramuzzino ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Pain Behavior ◽  
Female Rats ◽  
Formalin Injection ◽  
Male And Female ◽  
Male And Female Rats
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