scholarly journals Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic‐induced DNA damage and repair in normal human liver cells

2021 ◽  
Vol 41 (4) ◽  
pp. 650-650
Author(s):  
An‐liu Zhang ◽  
Shun‐fang Tang ◽  
Yue Yang ◽  
Chang‐zhe Li ◽  
Xue‐jiao Ding ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Liver Cells ◽  
Histone Demethylase ◽  
Dna Damage And Repair ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human ◽  
H3k9 Dimethylation

Histone demethylase JHDM2A regulates H3K9 dimethylation in response to arsenic‐induced DNA damage and repair in normal human liver cells

2020 ◽  
Vol 40 (12) ◽  
pp. 1661-1672
Author(s):  
An‐liu Zhang ◽  
Shun‐fang Tang ◽  
Yue Yang ◽  
Chang‐zhe Li ◽  
Xue‐jiao Ding ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Liver Cells ◽  
Histone Demethylase ◽  
Dna Damage And Repair ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human ◽  
H3k9 Dimethylation

scholarly journals Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells

Toxins ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 164 ◽  
Author(s):  
Lv Chen ◽  
Shu Yang ◽  
Cong Wen ◽  
Shuilin Zheng ◽  
Yue Yang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Expression Level ◽  
Tail Moment ◽  
Protein Expression Level ◽  
Over Expression ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human ◽  
Cyclic Heptapeptide

Microcystin-LR is a cyclic heptapeptide hepatotoxin produced by harmful cyanobacteria. A panel of microRNAs containing miR-451a were found to be significantly changed in normal human liver cells HL7702 after exposure to microcystin-LR (MC-LR) in our previous study. However, the functions of miR-451a in hepatotoxicity induced by MC-LR remained unclear. The study aimed to investigate the impacts of miR-451a in HL7702 cells following treatment with 5 or 10 μM MC-LR. The comet assay indicated that MC-LR can influence Olive tail moment (OTM) in HL7702 cells. Furthermore, increase of miR-451a significantly repressed DNA damage and the protein expression level of γ-H2AX induced by MC-LR. Moreover, over-expression of miR-451a inhibited the expression level of p-AKT1 protein in cells following treatment by MC-LR. These results showed that miR-451a may protect from MC-LR-induced DNA damage by down-regulating the expression of p-AKT1, which provides new clues for the diagnosis and therapy policies for liver damage induced by MC-LR.

scholarly journals Effect of fumonisin B1 on the cell cycle of normal human liver cells

2013 ◽  
Vol 7 (6) ◽  
pp. 1970-1976 ◽  
Author(s):  
SHAO-KANG WANG ◽  
SHA LIU ◽  
LI-GANG YANG ◽  
RUO-FU SHI ◽  
GUI-JU SUN
Keyword(s):  
Cell Cycle ◽  
Human Liver ◽  
Fumonisin B1 ◽  
Liver Cells ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human

Transcriptome analysis in normal human liver cells exposed to 2, 3, 3′, 4, 4′, 5 - Hexachlorobiphenyl (PCB 156)

Chemosphere ◽  
2020 ◽  
Vol 239 ◽  
pp. 124747 ◽  
Author(s):  
Ningning Chen ◽  
Qiuli Shan ◽  
Yu Qi ◽  
Wei Liu ◽  
Xiaojun Tan ◽  
...  
Keyword(s):  
Transcriptome Analysis ◽  
Human Liver ◽  
Liver Cells ◽  
Human Liver Cells ◽  
Normal Human Liver ◽  
Normal Human

TiO2nanoparticles induce oxidative DNA damage and apoptosis in human liver cells

2011 ◽  
Vol 7 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Ritesh K Shukla ◽  
Ashutosh Kumar ◽  
Deepak Gurbani ◽  
Alok K. Pandey ◽  
Shashi Singh ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Liver ◽  
Oxidative Dna Damage ◽  
Liver Cells ◽  
Human Liver Cells
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