Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice

2021 ◽  
Author(s):  
Tin‐Tin Win‐Shwe ◽  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Hirohisa Takano
Keyword(s):  
Bisphenol A ◽  
Memory Function ◽  
Dietary Exposure ◽  
Allergic Asthmatic

scholarly journals Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A

2019 ◽  
Vol 16 (19) ◽  
pp. 3770 ◽  
Author(s):  
Tin-Tin Win-Shwe ◽  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Hirohisa Takano
Keyword(s):  
Object Recognition ◽  
Nmda Receptor ◽  
Bisphenol A ◽  
Allergic Asthma ◽  
Real Time ◽  
Memory Function ◽  
High Dose ◽  
Novel Object Recognition ◽  
Novel Object ◽  
Allergic Asthmatic

Bisphenol A (BPA) is a major constituent of plastic products, including epoxy resin containers, mobile phones, dental sealants, as well as electronic and medical equipment. BPA is recognized as an endocrine system-disrupting chemical which has toxic effects on the brain and reproductive system. However, little is known about the effects of co-exposure of BPA with allergens on the memory function and neurological as well as immunological biomarker levels. In this study, we examined the effects of intratracheal instillation of BPA on the memory function and neuroimmune biomarker levels using a mouse model of allergic asthma. Male C3H/HeJ Jcl mice were given three doses of BPA (0.0625 pmol, 1.25 pmol, and 25 pmol BPA/animal) intratracheally once a week, and ovalbumin (OVA) intratracheally every other week from 5 to 11 weeks old. At 11 weeks of age, a novel object recognition test was conducted after the final administration of OVA, and the hippocampi and hypothalami of the animals were collected after 24 h. The expression levels of the memory function-related genes N-methyl-D-aspartate (NMDA) receptor subunits, inflammatory cytokines, microglia markers, estrogen receptor-alpha, and oxytocin receptor were examined by real-time RT-PCR (real-time reverse transcription polymerase chain reaction) and immunohistochemical methods. Impairment of the novel object recognition ability was observed in the high-dose BPA-exposed mice with allergic asthma. In addition, the allergic asthmatic mice also showed downregulation of neurological biomarkers, such as NMDA receptor subunit NR2B in the hippocampus but no significant effect on immunological biomarkers in the hypothalamus. These findings suggest that exposure to high-dose BPA triggered impairment of memory function in the allergic asthmatic mice. This is the first study to show that, in the presence of allergens, exposure to high-dose BPA may affect memory by modulating the memory function-related genes in the hippocampus.

scholarly journals Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure

2011 ◽  
Vol 123 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Justin G. Teeguarden ◽  
Antonia M. Calafat ◽  
Xiaoyum Ye ◽  
Daniel R. Doerge ◽  
Mona I. Churchwell ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Urine ◽  
Dietary Exposure ◽  
Human Urine And Serum ◽  
Urine And Serum

Impact of dietary exposure to low-dose tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice

2021 ◽  
pp. 1-12
Author(s):  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Tin-Tin Win-Shwe ◽  
Maiko Kawaguchi ◽  
Hirohisa Takano
Keyword(s):  
Low Dose ◽  
Dietary Exposure ◽  
Allergic Asthmatic

scholarly journals Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1448
Author(s):  
Claudia Tonini ◽  
Marco Segatto ◽  
Simone Gagliardi ◽  
Simona Bertoli ◽  
Alessandro Leone ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Low Dose ◽  
Fetal Brain ◽  
Dietary Exposure ◽  
Estrogen Receptor Α ◽  
Protein Prenylation ◽  
Synthetic Compound ◽  
Mva Pathway ◽  
And Function ◽  
The Brain

Bisphenol A (BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure is widespread and more than 90% of individuals have detectable amounts of the molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal exposure to BPA affects the mevalonate (MVA) pathway in rat brain fetuses, and whether potential effects are sex-dependent. The MVA pathway is important for brain development and function. Our results demonstrate that the fetal brain, exposed in utero to a very low dose of BPA (2.5 µg/kg/day), displayed altered MVA pathway activation, increased protein prenylation, and a decreased level of pro-BDNF. Interestingly, the BPA-induced effects on estrogen receptor α were sex-dependent. In conclusion, this work demonstrates intergenerational effects of BPA on the brain at very low doses. Our results reveal new targets for BPA-induced interference and underline the impacts of BPA on health.

Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province

2019 ◽  
Vol 294 ◽  
pp. 160-170 ◽  
Author(s):  
Jian Zhou ◽  
Xiao-Hong Chen ◽  
Sheng-Dong Pan ◽  
Jun-Lin Wang ◽  
Yi-Bin Zheng ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Dietary Exposure ◽  
Zhejiang Province ◽  
Bisphenol S

scholarly journals Concentrations of phthalates and bisphenol A in Norwegian foods and beverages and estimated dietary exposure in adults

2014 ◽  
Vol 73 ◽  
pp. 259-269 ◽  
Author(s):  
Amrit K. Sakhi ◽  
Inger Therese L. Lillegaard ◽  
Stefan Voorspoels ◽  
Monica H. Carlsen ◽  
Elin B. Løken ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Dietary Exposure

Bisphenol A and nonylphenol in foodstuffs: Chinese dietary exposure from the 2007 total diet study and infant health risk from formulas

2015 ◽  
Vol 167 ◽  
pp. 320-325 ◽  
Author(s):  
Yumin Niu ◽  
Jing Zhang ◽  
Hejun Duan ◽  
Yongning Wu ◽  
Bing Shao
Keyword(s):  
Health Risk ◽  
Bisphenol A ◽  
Infant Health ◽  
Dietary Exposure ◽  
Total Diet Study ◽  
Total Diet ◽  
Diet Study
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