Epigenetic Effects of Bisphenol A (BPA): A Literature Review in the Context of Human Dietary Exposure

2017 ◽  
pp. 1-20
Author(s):  
Luísa Camacho ◽  
Igor P. Pogribny
Keyword(s):  
Literature Review ◽  
Bisphenol A ◽  
Dietary Exposure ◽  
Epigenetic Effects

scholarly journals Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure

2011 ◽  
Vol 123 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Justin G. Teeguarden ◽  
Antonia M. Calafat ◽  
Xiaoyum Ye ◽  
Daniel R. Doerge ◽  
Mona I. Churchwell ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Human Urine ◽  
Dietary Exposure ◽  
Human Urine And Serum ◽  
Urine And Serum

scholarly journals Epigenetic Effects of Environmental Chemicals Bisphenol A and Phthalates

2012 ◽  
Vol 13 (8) ◽  
pp. 10143-10153 ◽  
Author(s):  
Sher Singh ◽  
Steven Shoei-Lung Li
Keyword(s):  
Bisphenol A ◽  
Environmental Chemicals ◽  
Epigenetic Effects

scholarly journals Epigenetic effects of Bisphenol A on granulosa cells of mouse follicles during in vitro culture: An experimental study

2021 ◽  
Author(s):  
Aylin Jamali Khaghani ◽  
Parisa Farrokh ◽  
Saeed Zavareh
Keyword(s):  
Bisphenol A ◽  
Granulosa Cells ◽  
Promoter Methylation ◽  
Inhibitory Effect ◽  
Promoter Regions ◽  
Endocrine Disrupting Chemical ◽  
Epigenetic Effects ◽  
Endocrine Disrupting ◽  
The Impact

Background: Bisphenol A (BPA), a synthetic endocrine-disrupting chemical, is a reproductive toxicant. Granulosa cells have significant roles in follicle development, and KIT ligand (KITL) and Anti-Müllerian hormone (AMH) are essential biomolecules produced by them during folliculogenesis. Objective: Due to the widespread use of BPA and its potential epigenetic effects, this study examined the impact of BPA on promoter methylation of amh and kitl genes in mouse granulosa cells. Materials and Methods: Preantral follicles were isolated from ovaries of immature mice and cultured for eight days. Then, follicles were treated with 50 and 100 μM of BPA, and 0.01% (v/v) ethanol for 24 and 72 hr. Growth and degeneration of follicles and antrum formation were analyzed. The granulosa cells were isolated mechanically, and their extracted DNA was treated with sodium bisulfite. The promoter regions of the amh and kitl were analyzed with PCR and sequencing. Results: BPA did not change follicle survival and antrum formation significantly (p = 0.41). However, the culture in the presence of 100 μM BPA had an inhibitory effect on growth. Before BPA treatment, the CpG of the kitl and amh promoters were unmethylated and partially methylated, respectively. While the percent of 5mC in the amh promoter reduced at 100 μM of BPA, it did not alter the kitl promoter methylation. Conclusion: BPA at higher concentrations has an inhibitory effect on follicle growth. Moreover, it seems that the epigenetic impact of BPA restricts to the demethylation of CpG sites. Key words: Bisphenol A, DNA methylation, Granulosa cells.

scholarly journals Maternal Dietary Exposure to Low-Dose Bisphenol A Affects Metabolic and Signaling Pathways in the Brain of Rat Fetuses

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1448
Author(s):  
Claudia Tonini ◽  
Marco Segatto ◽  
Simone Gagliardi ◽  
Simona Bertoli ◽  
Alessandro Leone ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Low Dose ◽  
Fetal Brain ◽  
Dietary Exposure ◽  
Estrogen Receptor Α ◽  
Protein Prenylation ◽  
Synthetic Compound ◽  
Mva Pathway ◽  
And Function ◽  
The Brain

Bisphenol A (BPA) is a synthetic compound widely used for the production of polycarbonate plasticware and epoxy resins. BPA exposure is widespread and more than 90% of individuals have detectable amounts of the molecule in their body fluids, which originates primarily from diet. Here, we investigated whether prenatal exposure to BPA affects the mevalonate (MVA) pathway in rat brain fetuses, and whether potential effects are sex-dependent. The MVA pathway is important for brain development and function. Our results demonstrate that the fetal brain, exposed in utero to a very low dose of BPA (2.5 µg/kg/day), displayed altered MVA pathway activation, increased protein prenylation, and a decreased level of pro-BDNF. Interestingly, the BPA-induced effects on estrogen receptor α were sex-dependent. In conclusion, this work demonstrates intergenerational effects of BPA on the brain at very low doses. Our results reveal new targets for BPA-induced interference and underline the impacts of BPA on health.

Contamination status of bisphenol A and its analogues (bisphenol S, F and B) in foodstuffs and the implications for dietary exposure on adult residents in Zhejiang Province

2019 ◽  
Vol 294 ◽  
pp. 160-170 ◽  
Author(s):  
Jian Zhou ◽  
Xiao-Hong Chen ◽  
Sheng-Dong Pan ◽  
Jun-Lin Wang ◽  
Yi-Bin Zheng ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Dietary Exposure ◽  
Zhejiang Province ◽  
Bisphenol S

scholarly journals Concentrations of phthalates and bisphenol A in Norwegian foods and beverages and estimated dietary exposure in adults

2014 ◽  
Vol 73 ◽  
pp. 259-269 ◽  
Author(s):  
Amrit K. Sakhi ◽  
Inger Therese L. Lillegaard ◽  
Stefan Voorspoels ◽  
Monica H. Carlsen ◽  
Elin B. Løken ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Dietary Exposure

Dietary exposure to bisphenol A affects memory function and neuroimmune biomarkers in allergic asthmatic mice

2021 ◽  
Author(s):  
Tin‐Tin Win‐Shwe ◽  
Rie Yanagisawa ◽  
Eiko Koike ◽  
Hirohisa Takano
Keyword(s):  
Bisphenol A ◽  
Memory Function ◽  
Dietary Exposure ◽  
Allergic Asthmatic

Bisphenol A and nonylphenol in foodstuffs: Chinese dietary exposure from the 2007 total diet study and infant health risk from formulas

2015 ◽  
Vol 167 ◽  
pp. 320-325 ◽  
Author(s):  
Yumin Niu ◽  
Jing Zhang ◽  
Hejun Duan ◽  
Yongning Wu ◽  
Bing Shao
Keyword(s):  
Health Risk ◽  
Bisphenol A ◽  
Infant Health ◽  
Dietary Exposure ◽  
Total Diet Study ◽  
Total Diet ◽  
Diet Study
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