Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO‐1/NQO1 pathway

2021 ◽  
Author(s):  
Qiang Lu ◽  
Ying Zhang ◽  
Chao Zhao ◽  
Hu Zhang ◽  
Yuepu Pu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hippocampal Neuron

scholarly journals Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus

Seizure ◽  
2010 ◽  
Vol 19 (3) ◽  
pp. 165-172 ◽  
Author(s):  
Jinzhi Liu ◽  
Aihua Wang ◽  
Lili Li ◽  
Yanfei Huang ◽  
Ping Xue ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Status Epilepticus ◽  
Hippocampal Neuron ◽  
Neuron Death

scholarly journals Naofucong Ameliorates High Glucose Induced Hippocampal Neuron Injury Through Suppressing P2X7/NLRP1/Caspase-1 Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Guangchan Jing ◽  
Huanyuan Wang ◽  
Fengwei Nan ◽  
Yuqin Liu ◽  
Mengren Zhang
Keyword(s):  
Oxidative Stress ◽  
High Glucose ◽  
Hippocampal Neurons ◽  
Hippocampal Neuron ◽  
Neuronal Injury ◽  
Protective Effects ◽  
Ht22 Cells ◽  
Caspase 1 ◽  
Neuron Injury ◽  
Cells Cultured

P2X7/NLRP1/caspase-1 mediated neuronal injury plays an important role in diabetic cognitive impairment and eventually inflammatory cascade reaction. Chinese herbal compound Naofucong has been mainly used to treat cognitive disorders in Traditional Chinese Medicine The present study aimed to investigate whether its neuroprotective effects might be related to the inhibition of P2X7R/NLRP1/caspase-1 mediated neuronal injury or not. In this study, high glucose-induced HT22 hippocampal neurons were used to determine Naofucong-containing serum neuronal protective effects. Lentiviruses knock out of TXNIP and P2X7R was used to determine that protective effects of Naofucong was related to inflammatory response and P2X7/NLRP1/caspase-1 mediated neuronal injury. NAC was also used to inhibit oxidative stress, so as to determine that oxidative stress is an important starting factor for neuronal injury of HT22 cells cultured with high glucose. Naofucong decreased apoptosis, IL-1β and IL-18 levels in high glucose-induced HT22 hippocampal neuron cells. Naofucong suppressed NLRP1/caspase-1 mediated neuronal injury, and P2X7 was involved in process. HT22 cells cultured in high glucose had an internal environment with elevated oxidative stress, which could promote neuronal injury. The current study demonstrated that Naofucong could significantly improve high glucose-induced HT22 hippocampal neuron injury, which might be related to suppress P2X7R/NLRP1/caspase-1 pathway, which provides novel evidence to support the future clinical use of Naofucong.

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