Design and evaluation of nanostructured lipid carriers loaded with Salvia officinalis extract for Alzheimer's disease treatment

2022 ◽  
Author(s):  
Elena Markova ◽  
Lea Taneska ◽  
Monika Kostovska ◽  
Dushko Shalabalija ◽  
Ljubica Mihailova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nanostructured Lipid Carriers ◽  
Salvia Officinalis ◽  
Disease Treatment

scholarly journals Freeze-drying of nanostructured lipid carriers loaded with Salvia off. extract for Alzheimer’s disease treatment

2020 ◽  
Vol 66 (03) ◽  
pp. 219-220
Author(s):  
Iskra Karakash ◽  
Jovana Vasileska ◽  
Dushko Shalabalija ◽  
Ljubica Mihailova ◽  
Marija Glavas Dodov ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Freeze Drying ◽  
Nanostructured Lipid Carriers ◽  
Disease Treatment

Therapeutic Properties of Several Chemical Compounds from Salvia officinalis L. in Alzheimer’s Disease

2020 ◽  
Vol 21 ◽  
Author(s):  
Georgiana Uță ◽  
Denisa Ștefania Manolescu ◽  
Speranța Avram
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Side Effects ◽  
Chemical Compounds ◽  
Natural Compounds ◽  
Salvia Officinalis ◽  
Chemical Structures ◽  
In Silico Studies ◽  
Wide Range ◽  
Salvia Officinalis L

Background.: Currently, the pharmacological management in Alzheimer's disease is based on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate (NMDA) receptor ligands, with still unclear molecular mechanisms, but severe side effects. For this reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side effects. Recently, the natural compounds, in particular certain chemical compounds identified in the essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible therapeutics. Objectives.: In this paper, we have summarized data from the recent literature, on several chemical compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease. Methods.: In addition to the wide range of experimental methods performed in vivo and in vitro, also we presented some in silico studies of medicinal compounds. Results. Through this mini-review, we present the latest information regarding the therapeutic characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease. Conclusion.: Thus, based on the information presented, we can say that phytotherapy is a reliable therapeutic method in a neurodegenerative disease.

Huprine Y – tryptophan heterodimers with potential implication to Alzheimer’s disease treatment

2021 ◽  
pp. 128100
Author(s):  
Eva Mezeiova ◽  
Martina Hrabinova ◽  
Vendula Hepnarova ◽  
Daniel Jun ◽  
Jana Janockova ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Treatment ◽  
Potential Implication

Computational modelling of potent β-secretase (BACE1) inhibitors towards Alzheimer's disease treatment

2021 ◽  
Vol 270 ◽  
pp. 106536
Author(s):  
Samuel C. Ugbaja ◽  
Zainab K. Sanusi ◽  
Patrick Appiah-Kubi ◽  
Monsurat M. Lawal ◽  
Hezekiel M. Kumalo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Computational Modelling ◽  
Disease Treatment

Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer’s disease treatment

2013 ◽  
Vol 23 (11) ◽  
pp. 3467-3469 ◽  
Author(s):  
Seong Rim Byeon ◽  
Hyunjin Vincent Kim ◽  
Mijin Jeon ◽  
Young Gil Ahn ◽  
Maeng Sup Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Treatment
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