Author response for "Bone vasculature and bone marrow vascular niches in health and disease"

2020 ◽  
Author(s):  
Junyu Chen ◽  
Michelle Hendriks ◽  
Alexandros Chatzis ◽  
Saravana K. Ramasamy ◽  
Anjali P. Kusumbe
Keyword(s):  
Bone Marrow ◽  
Author Response ◽  
Health And Disease ◽  
Bone Vasculature

Author response for "Bone vasculature and bone marrow vascular niches in health and disease"

2020 ◽  
Author(s):  
Junyu Chen ◽  
Michelle Hendriks ◽  
Alexandros Chatzis ◽  
Saravana K. Ramasamy ◽  
Anjali P. Kusumbe
Keyword(s):  
Bone Marrow ◽  
Author Response ◽  
Health And Disease ◽  
Bone Vasculature

scholarly journals Bone Vasculature and Bone Marrow Vascular Niches in Health and Disease

2020 ◽  
Vol 35 (11) ◽  
pp. 2103-2120 ◽  
Author(s):  
Junyu Chen ◽  
Michelle Hendriks ◽  
Alexandros Chatzis ◽  
Saravana K Ramasamy ◽  
Anjali P Kusumbe
Keyword(s):  
Bone Marrow ◽  
Health And Disease ◽  
Bone Vasculature

Author response for "CXCR4, but not CXCR3, drives CD8 T-cell entry into and migration through the murine bone marrow"

2018 ◽  
Author(s):  
Marieke Goedhart ◽  
Stephanie Gessel ◽  
Robbert van der Voort ◽  
Edith Slot ◽  
Beth Lucas ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Entry ◽  
Author Response ◽  
Murine Bone Marrow ◽  
And Migration

scholarly journals Quantification of plasma cell dynamics using mathematical modelling

2018 ◽  
Vol 5 (1) ◽  
pp. 170759 ◽  
Author(s):  
Marcel Mohr ◽  
Dirk Hose ◽  
Anja Seckinger ◽  
Anna Marciniak-Czochra
Keyword(s):  
Mathematical Model ◽  
Bone Marrow ◽  
Mathematical Modelling ◽  
Plasma Cells ◽  
Cell Dynamics ◽  
Growth And Survival ◽  
Specific Antibodies ◽  
Health And Disease ◽  
Potential Basis ◽  
The Impact

Plasma cells (PCs) are the main antibody-producing cells in humans. They are long-lived so that specific antibodies against either pathogens or vaccines are produced for decades. PC longevity is attributed to specific areas within the bone marrow micro-environment, the so-called ‘niche’, providing the cells with required growth and survival factors. With antigen encounters, e.g. infection or vaccination, new PCs are generated and home to the bone marrow where they compete with resident PCs for the niche. We propose a parametrized mathematical model describing healthy PC dynamics in the bone marrow. The model accounts for competition for the niche between newly produced PCs owing to vaccination and resident PCs. Mathematical analysis and numerical simulations of the model allow explanation of the recovery of PC homoeostasis after a vaccine-induced perturbation, and the fraction of vaccine-specific PCs inside the niche. The model enables quantification of the niche-related dynamics of PCs, i.e. the duration of PC transition into the niche and the impact of different rates for PC transitions into and out of the niche on the observed cell dynamics. Ultimately, it provides a potential basis for further investigations in health and disease.

scholarly journals 3D models of the bone marrow in health and disease: yesterday, today, and tomorrow

2018 ◽  
Vol 9 (01) ◽  
pp. 37-52 ◽  
Author(s):  
Annamarija Raic ◽  
Toufik Naolou ◽  
Anna Mohra ◽  
Chandralekha Chatterjee ◽  
Cornelia Lee-Thedieck
Keyword(s):  
Bone Marrow ◽  
3D Models ◽  
Health And Disease ◽  
Image Position

Abstract

Sign in / Sign up

Export Citation Format

Share Document