A novel quercetin analogue from a medicinal plant promotes peak bone mass achievement and bone healing after injury and exerts an anabolic effect on osteoporotic bone: The role of aryl hydrocarbon receptor as a mediator of osteogenic action

2011 ◽  
Vol 26 (9) ◽  
pp. 2096-2111 ◽  
Author(s):  
Kunal Sharan ◽  
Jay Sharan Mishra ◽  
Gaurav Swarnkar ◽  
Jawed Akhtar Siddiqui ◽  
Kainat Khan ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Bone Mass ◽  
Aryl Hydrocarbon Receptor ◽  
Bone Healing ◽  
Peak Bone Mass ◽  
Osteoporotic Bone ◽  
Anabolic Effect ◽  
Aryl Hydrocarbon

A naturally occurring rare analog of quercetin promotes peak bone mass achievement and exerts anabolic effect on osteoporotic bone

2011 ◽  
Vol 22 (12) ◽  
pp. 3013-3027 ◽  
Author(s):  
J. A. Siddiqui ◽  
G. Swarnkar ◽  
K. Sharan ◽  
B. Chakravarti ◽  
A. K. Gautam ◽  
...  
Keyword(s):  
Bone Mass ◽  
Peak Bone Mass ◽  
Osteoporotic Bone ◽  
Anabolic Effect ◽  
Naturally Occurring

Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon

2021 ◽  
pp. 2100539
Author(s):  
Robert S. Chapkin ◽  
Laurie A. Davidson ◽  
Hyejin Park ◽  
Un‐Ho Jin ◽  
Yang‐Yi Fan ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon

Role of the Aryl Hydrocarbon Receptor in the Pathogenesis of Chronic Rhinosinusitis with Nasal Polyps

Inflammation ◽  
2013 ◽  
Vol 37 (2) ◽  
pp. 387-395 ◽  
Author(s):  
Ping Wei ◽  
Guo-hua Hu ◽  
Hou-yong Kang ◽  
Hong-bing Yao ◽  
Wei Kou ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Chronic Rhinosinusitis ◽  
Nasal Polyps ◽  
Aryl Hydrocarbon

scholarly journals Author response: Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury

2020 ◽  
Author(s):  
Michelle M Lissner ◽  
Katherine Cumnock ◽  
Nicole M Davis ◽  
José G Vilches-Moure ◽  
Priyanka Basak ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Metabolic Profiling ◽  
Kidney Injury ◽  
Author Response ◽  
Aryl Hydrocarbon

scholarly journals Immunotoxicity of Xenobiotics in Fish: A Role for the Aryl Hydrocarbon Receptor (AhR)?

2021 ◽  
Vol 22 (17) ◽  
pp. 9460
Author(s):  
Helmut Segner ◽  
Christyn Bailey ◽  
Carolina Tafalla ◽  
Jun Bo
Keyword(s):  
Immune System ◽  
Aryl Hydrocarbon Receptor ◽  
Disease Susceptibility ◽  
Immune Cell ◽  
Physiological Role ◽  
Immune Gene ◽  
Immune Systems ◽  
Aryl Hydrocarbon ◽  
The Impact

The impact of anthropogenic contaminants on the immune system of fishes is an issue of growing concern. An important xenobiotic receptor that mediates effects of chemicals, such as halogenated aromatic hydrocarbons (HAHs) and polyaromatic hydrocarbons (PAHs), is the aryl hydrocarbon receptor (AhR). Fish toxicological research has focused on the role of this receptor in xenobiotic biotransformation as well as in causing developmental, cardiac, and reproductive toxicity. However, biomedical research has unraveled an important physiological role of the AhR in the immune system, what suggests that this receptor could be involved in immunotoxic effects of environmental contaminants. The aims of the present review are to critically discuss the available knowledge on (i) the expression and possible function of the AhR in the immune systems of teleost fishes; and (ii) the impact of AhR-activating xenobiotics on the immune systems of fish at the levels of immune gene expression, immune cell proliferation and immune cell function, immune pathology, and resistance to infectious disease. The existing information indicates that the AhR is expressed in the fish immune system, but currently, we have little understanding of its physiological role. Exposure to AhR-activating contaminants results in the modulation of numerous immune structural and functional parameters of fish. Despite the diversity of fish species studied and the experimental conditions investigated, the published findings rather uniformly point to immunosuppressive actions of xenobiotic AhR ligands in fish. These effects are often associated with increased disease susceptibility. The fact that fish populations from HAH- and PAH-contaminated environments suffer immune disturbances and elevated disease susceptibility highlights that the immunotoxic effects of AhR-activating xenobiotics bear environmental relevance.

scholarly journals Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation

2016 ◽  
Vol 23 (8) ◽  
pp. 960-975 ◽  
Author(s):  
Shunsuke Ito ◽  
Mizuko Osaka ◽  
Takeo Edamatsu ◽  
Yoshiharu Itoh ◽  
Masayuki Yoshida
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Crucial Role ◽  
Vascular Inflammation ◽  
Indoxyl Sulfate ◽  
Aryl Hydrocarbon
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