S19 ribosomal protein dimer augments metal-induced apoptosis in a mouse fibroblastic cell line by ligation of the C5a receptor

2005 ◽  
Vol 94 (3) ◽  
pp. 540-553 ◽  
Author(s):  
Hiroshi Nishiura ◽  
Sumio Tanase ◽  
Yoko Shibuya ◽  
Noriko Futa ◽  
Tamami Sakamoto ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Cell Line ◽  
Fibroblastic Cell ◽  
C5a Receptor ◽  
Protein Dimer ◽  
Induced Apoptosis ◽  
S19 Ribosomal Protein

Apoptotic Cells of an Epithelial Cell Line, AsPC-1, Release Monocyte Chemotactic S19 Ribosomal Protein Dimer

2001 ◽  
Vol 129 (3) ◽  
pp. 445-454 ◽  
Author(s):  
T. Nishimura ◽  
K. Horino ◽  
H. Nishiura ◽  
Y. Shibuya ◽  
T. Hiraoka ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Ribosomal Protein ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Apoptotic Cells ◽  
Protein Dimer ◽  
S19 Ribosomal Protein

scholarly journals Switch Moiety in Agonist/Antagonist Dual Effect of S19 Ribosomal Protein Dimer on Leukocyte Chemotactic C5a Receptor

2003 ◽  
Vol 162 (4) ◽  
pp. 1381-1388 ◽  
Author(s):  
Arjun Shrestha ◽  
Megumi Shiokawa ◽  
Takumasa Nishimura ◽  
Hiroshi Nishiura ◽  
Yuji Tanaka ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Dual Effect ◽  
C5a Receptor ◽  
Protein Dimer ◽  
S19 Ribosomal Protein

Agonist and antagonist dual effect of the cross-linked S19 ribosomal protein dimer in the C5a receptor-mediated respiratory burst reaction of phagocytic leukocytes

2005 ◽  
Vol 54 (2) ◽  
pp. 82-90 ◽  
Author(s):  
I. Revollo ◽  
H. Nishiura ◽  
Y. Shibuya ◽  
Y. Oda ◽  
N. Nishino ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Respiratory Burst ◽  
Dual Effect ◽  
C5a Receptor ◽  
Protein Dimer ◽  
Agonist And Antagonist ◽  
The Cross ◽  
S19 Ribosomal Protein

Agonistic and Antagonistic Effects of C5a-Chimera Bearing S19 Ribosomal Protein Tail Portion on the C5a Receptor of Monocytes and Neutrophils, Respectively

2008 ◽  
Vol 144 (3) ◽  
pp. 371-381 ◽  
Author(s):  
Y. Oda ◽  
K. Tokita ◽  
Y. Ota ◽  
Y. Li ◽  
K. Taniguchi ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
C5a Receptor ◽  
Antagonistic Effects ◽  
S19 Ribosomal Protein

Guinea pig S19 ribosomal protein as precursor of C5a receptor-directed monocyte-selective leukocyte chemotactic factor

2004 ◽  
Vol 53 (11) ◽  
pp. 623-630 ◽  
Author(s):  
Y. Umeda ◽  
Y. Shibuya ◽  
U. Semba ◽  
K. Tokita ◽  
N. Nishino ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Ribosomal Protein ◽  
Chemotactic Factor ◽  
C5a Receptor ◽  
S19 Ribosomal Protein

Monocyte chemotactic S19 ribosomal protein dimer in atherosclerotic vascular lesion

2005 ◽  
Vol 447 (4) ◽  
pp. 747-755 ◽  
Author(s):  
Lei Shi ◽  
Shigeyuki Tsurusaki ◽  
Noriko Futa ◽  
Tamami Sakamoto ◽  
Tomoko Matsuda ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Vascular Lesion ◽  
Protein Dimer ◽  
S19 Ribosomal Protein

scholarly journals Identification of Receptor-Binding Sites of Monocyte Chemotactic S19 Ribosomal Protein Dimer

2001 ◽  
Vol 159 (6) ◽  
pp. 2293-2301 ◽  
Author(s):  
Yoko Shibuya ◽  
Megumi Shiokawa ◽  
Hiroshi Nishiura ◽  
Takumasa Nishimura ◽  
Norikazu Nishino ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Receptor Binding ◽  
Binding Sites ◽  
Protein Dimer ◽  
S19 Ribosomal Protein

Apoptotic Effects of N-(2-hydroxyphenyl)-2-propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties

2020 ◽  
Vol 20 ◽  
Author(s):  
Paola Castillo-Juárez ◽  
Sebastián C. Sanchez ◽  
Alma D. Chávez-Blanco ◽  
Humberto Mendoza-Figueroa ◽  
José Correa-Basurto
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Histone Deacetylases ◽  
Biochemical Mechanism ◽  
Antiproliferative Effects ◽  
Human Osteosarcoma ◽  
Antiproliferative Agent ◽  
Induced Apoptosis ◽  
Apoptotic Effects

Background and Objective: Histone deacetylases (HDACs) are important therapeutic targets for many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), has antiproliferative properties on some cancer cell lines and inhibits the HDAC1 isoform. Materials and Methods: In this work, HO-AAVPA was tested as an antiproliferative agent in U87-MG (human glioblastoma) and U-2 OS cells (human osteosarcoma), which are types of cancer that are difficult to treat, and its antiangiogenic properties were explored. Results: HO-AAVPA had antiproliferative effects at 48 h with an IC50 = 0.655 mM in U87-MG cells and an IC50 = 0.453 mM in U-2 OS cells. Additionally, in the colony formation assay, HO-AAVPA decreased the number of colonies by approximately 99% in both cell lines and induced apoptosis by 31.3% in the U-2 OS cell line and by 78.2% in the U87-MG cell line. Additionally, HO-AAVPA reduced the number of vessels in chorioallantoid membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical mechanism on cancer cell of HO-AAVPA is different compared to VPA. Conclusion: HO-AAVPA has antiproliferative effects on glioblastoma and osteosarcoma and antiangiogenic properties.

Sign in / Sign up

Export Citation Format

Share Document