Breviscapine provides a neuroprotective effect after traumatic brain injury by modulating the Nrf2 signaling pathway

2019 ◽  
Vol 120 (9) ◽  
pp. 14899-14907 ◽  
Author(s):  
Fayin Li ◽  
Xiaodong Wang ◽  
Zhijie Zhang ◽  
Pengfei Gao ◽  
Xianlong Zhang
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Signaling Pathway ◽  
Neuroprotective Effect ◽  
Nrf2 Signaling Pathway

scholarly journals Docosahexaenoic Acid Protects Traumatic Brain Injury by Regulating NOX2 Generation via Nrf2 Signaling Pathway

2020 ◽  
Vol 45 (8) ◽  
pp. 1839-1850
Author(s):  
Wei Zhu ◽  
Guangqiang Cui ◽  
Tuo Li ◽  
Hongguang Chen ◽  
Jian Zhu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Docosahexaenoic Acid ◽  
Signaling Pathway ◽  
Nrf2 Signaling Pathway

Erythropoietin Administration Modulates Pulmonary Nrf2 Signaling Pathway After Traumatic Brain Injury in Mice

2011 ◽  
Vol 71 (3) ◽  
pp. 680-686 ◽  
Author(s):  
Wei Jin ◽  
Jun Wu ◽  
Handong Wang ◽  
Jie Kong ◽  
Hongbin Ni ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Signaling Pathway ◽  
Nrf2 Signaling Pathway

Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats via activation of the PI3K/Akt/Nrf2 signaling pathway

2021 ◽  
Author(s):  
Changchang Fu ◽  
Yihui Zheng ◽  
Kun Lin ◽  
Hongzeng Wang ◽  
Tingting Chen ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Injury ◽  
Signaling Pathway ◽  
Neuroprotective Effect ◽  
Ischemic Brain Injury ◽  
Neonatal Rats ◽  
Ischemic Brain ◽  
Nrf2 Signaling Pathway ◽  
Hypoxic Ischemic Brain Injury

Neonatal hypoxic-ischemic (HI) brain injury can lead to mortality and severe long-term disabilities including cerebral palsy and brain injury.

scholarly journals Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

2021 ◽  
Vol 13 (4) ◽  
pp. 62-69
Author(s):  
Dan Wang ◽  
Xiaoqing Dong
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Neuroprotective Effect ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Active Components ◽  
Nrf2 Pathway ◽  
Therapeutic Value ◽  
Nrf2 Signaling Pathway ◽  
Brain Tissues

Gastrodin is one of the main active components of Gastrodia elata and has significant therapeutic value for various nervous system diseases. Its medicinal properties include smooth muscle relaxation, anti-necrosis, anti-aging, and anti-apoptosis effects. However, its possible effects on traumatic brain injury (TBI) are still unclear. In this study, the effects of gastroditin on TBI rats were investigated. The results proved that gastrodin had neuroprotective effect on TBI through alleviating brain deficits, decreasing brain water content, inhibiting neuronal apoptosis, and suppressing oxidative stress in brain tissues of TBI rats. Mechanically, gastrodin upregulated the expression of Nrf2 downstream proteins, suggesting the activation of Nrf2 pathway in brain tissues of TBI rats. In conclusion, gastrodin provided neuroprotection in TBI rats via Nrf2 pathway.

scholarly journals Progesterone Provides the Pleiotropic Neuroprotective Effect on Traumatic Brain Injury Through the Nrf2/ARE Signaling Pathway

2016 ◽  
Vol 26 (2) ◽  
pp. 292-300 ◽  
Author(s):  
Mei Zhang ◽  
Jianyue Wu ◽  
Haojun Ding ◽  
Wentian Wu ◽  
Guomin Xiao
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Signaling Pathway ◽  
Neuroprotective Effect
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