Novel short synthetic matrix attachment region for enhancing transgenic expression in recombinant Chinese hamster ovary cells

2019 ◽  
Vol 120 (10) ◽  
pp. 18478-18486 ◽  
Author(s):  
Yan‐Long Jia ◽  
Xiao Guo ◽  
Tian‐Jun Ni ◽  
Jiang‐Tao Lu ◽  
Xiao‐Yin Wang ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Matrix Attachment Region ◽  
Ovary Cells ◽  
Transgenic Expression ◽  
Attachment Region ◽  
Synthetic Matrix

scholarly journals Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Chun-Peng Zhao ◽  
Xiao Guo ◽  
Si-Jia Chen ◽  
Chang-Zheng Li ◽  
Yun Yang ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Transgene Expression ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Matrix Attachment Region ◽  
Ovary Cells ◽  
Attachment Region

scholarly journals Regulating effects of insertion direction of matrix attachment regions on transgenic expression in stably transformed Chinese hamster ovary cells

2015 ◽  
Vol 14 (2) ◽  
pp. 7031-7038 ◽  
Author(s):  
F. Wang ◽  
J.H. Zhang ◽  
T.Y. Wang ◽  
W.H. Dong ◽  
X.J. Yang ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Matrix Attachment Regions ◽  
Ovary Cells ◽  
Transgenic Expression

scholarly journals A chimeric HS4 insulator-scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells

FEBS Open Bio ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 2021-2030 ◽  
Author(s):  
Si-jia Chen ◽  
Wen Wang ◽  
Feng-yi Zhang ◽  
Yan-long Jia ◽  
Xiao-yin Wang ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Transgene Expression ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Ovary Cells ◽  
Attachment Region ◽  
Scaffold Attachment Region

Malignancy-related characteristics of wild type and drug-resistant chinese hamster ovary cells

Pathology ◽  
1993 ◽  
Vol 25 (3) ◽  
pp. 268-276 ◽  
Author(s):  
Wanda B. Mackinnon ◽  
Marlen Dyne ◽  
Rebecca Hancock ◽  
Carolyn E. Mountford ◽  
Adrienne J. Grant ◽  
...  
Keyword(s):  
Chinese Hamster Ovary ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Drug Resistant ◽  
Wild Type ◽  
Ovary Cells

Review of the current methods of Chinese Hamster Ovary (CHO) cells cultivation for production of therapeutic protein

2020 ◽  
Vol 17 ◽  
Author(s):  
Shazid Md. Sharker ◽  
Md. Atiqur Rahman
Keyword(s):  
Chinese Hamster Ovary ◽  
Cho Cells ◽  
Mass Production ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Therapeutic Protein ◽  
Specific Productivity ◽  
Ovary Cells ◽  
Further Development ◽  
Interesting Area

Most of clinical approved protein-based drugs or under in clinical trial have a profound impact in the treatment of critical diseases. The mammalian eukaryotic cells culture approaches, particularly the CHO (Chinese Hamster Ovary) cells are mainly used in the biopharmaceutical industry for the mass-production of therapeutic protein. Recent advances in CHO cell bioprocessing to yield recombinant proteins and monoclonal antibodies have enabled the expression of quality protein. The developments of cell lines are possible to upgrade specific productivity. As a result, it holds an interesting area for academic as well as industrial researchers around the world. This review will concentrate on the recent progress of the mammalian CHO cells culture technology and the future scope of further development for the mass-production of protein therapeutics.

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