Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

2014 ◽  
Vol 54 (8) ◽  
pp. 937-948 ◽  
Author(s):  
Chihiro Hasegawa ◽  
Helen Kastrissios ◽  
Jonathan Monteleone ◽  
Tomoya Ohno ◽  
Takeo Umemura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Modeling And Simulation ◽  
Bone Mineral ◽  
Cathepsin K ◽  
Phase 2 ◽  
Mineral Density ◽  
Dose Selection ◽  
Cathepsin K Inhibitor ◽  
Phase 2 Study ◽  
Density Response

scholarly journals Romosozumab increases bone mineral density in postmenopausal Japanese women with osteoporosis: A phase 2 study

Bone ◽  
2017 ◽  
Vol 103 ◽  
pp. 209-215 ◽  
Author(s):  
Hideaki Ishibashi ◽  
Daria B. Crittenden ◽  
Akimitsu Miyauchi ◽  
Cesar Libanati ◽  
Judy Maddox ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Japanese Women ◽  
Phase 2 ◽  
Mineral Density ◽  
Phase 2 Study

Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover markers and bone mineral density in ovariectomized cynomolgus monkeys

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S70-S71 ◽  
Author(s):  
H. Yamada⁎ ◽  
H. Mori ◽  
A. Kunishige ◽  
S. Nishikawa ◽  
Y. Hashimoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Cathepsin K ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Cathepsin K Inhibitor ◽  
Turnover Markers

scholarly journals The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

2011 ◽  
Vol 26 (4) ◽  
pp. 303 ◽  
Author(s):  
Seung Hun Lee ◽  
Jung-Min Koh ◽  
Young-Sun Lee ◽  
Beom-Jun Kim ◽  
Je-Yong Choi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Animal Model ◽  
Combination Therapy ◽  
Bone Mineral ◽  
Cathepsin K ◽  
Mineral Density ◽  
Cathepsin K Inhibitor
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