Four-year results of a phase 2 study of the cathepsin K inhibitor odanacatib in postmenopausal women with low bone mineral density: Effects on bone mineral density and bone turnover markers

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S92
Author(s):  
H. Resch ◽  
N. Binkley ◽  
H. Bone ◽  
J. Eisman ◽  
D. Hosking ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Cathepsin K ◽  
Phase 2 ◽  
Mineral Density ◽  
Cathepsin K Inhibitor ◽  
Phase 2 Study ◽  
Turnover Markers

Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover markers and bone mineral density in ovariectomized cynomolgus monkeys

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S70-S71 ◽  
Author(s):  
H. Yamada⁎ ◽  
H. Mori ◽  
A. Kunishige ◽  
S. Nishikawa ◽  
Y. Hashimoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Cathepsin K ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Cathepsin K Inhibitor ◽  
Turnover Markers

Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

2014 ◽  
Vol 54 (8) ◽  
pp. 937-948 ◽  
Author(s):  
Chihiro Hasegawa ◽  
Helen Kastrissios ◽  
Jonathan Monteleone ◽  
Tomoya Ohno ◽  
Takeo Umemura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Modeling And Simulation ◽  
Bone Mineral ◽  
Cathepsin K ◽  
Phase 2 ◽  
Mineral Density ◽  
Dose Selection ◽  
Cathepsin K Inhibitor ◽  
Phase 2 Study ◽  
Density Response

High bone turnover markers and disturbances of bone mineral density in children with hypophosphataemic rickets

2017 ◽  
Author(s):  
Agnieszka Rusinska ◽  
Izabela Michalus ◽  
Izabela Woch ◽  
Paulina Adamiecka ◽  
Danuta Chlebna-Sokol
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Hypophosphataemic Rickets ◽  
High Bone Turnover ◽  
High Bone ◽  
Turnover Markers

Bone mineral density and bone turnover markers in patients with thyroid cancer and L-T4 suppressive therapy after 25 years of follow-up

2014 ◽  
Author(s):  
Mingo Dominguez Maria Luisa de ◽  
Sonsoles Guadalix Iglesias ◽  
Maria Begona Lopez Alvarez ◽  
Guillermo Martinez Diaz-Guerra ◽  
Federico Hawkins Carranza
Keyword(s):  
Bone Mineral Density ◽  
Thyroid Cancer ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Suppressive Therapy ◽  
Mineral Density ◽  
Turnover Markers

Bone mineral density and bone turnover markers in women with connective tissue dysplasia

2019 ◽  
Vol 17 (4) ◽  
pp. 102-106
Author(s):  
M. Yu. Smetanin ◽  
◽  
S. Yu. Nurgalieva ◽  
N. Yu. Kononova ◽  
L. T. Pimenov ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Connective Tissue ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Connective Tissue Dysplasia ◽  
Turnover Markers

Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women

Bone ◽  
2006 ◽  
Vol 39 (5) ◽  
pp. 1136-1143 ◽  
Author(s):  
Hussein F. Saadi ◽  
Nicolaas Nagelkerke ◽  
Sheela Benedict ◽  
Hussein S. Qazaq ◽  
Erica Zilahi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Turnover Markers

scholarly journals Association between Baseline Values of Bone Turnover Markers and Bone Mineral Density and Their Response to Raloxifene Treatment in Japanese Postmenopausal Women with Osteoporosis

2008 ◽  
Vol 55 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Takafumi MAJIMA ◽  
Akira SHIMATSU ◽  
Yasato KOMATSU ◽  
Noriko SATOH ◽  
Atsushi FUKAO ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Baseline Values ◽  
Turnover Markers

scholarly journals Effect of Denosumab on Bone Mineral Density and Markers of Bone Turnover among Postmenopausal Women with Osteoporosis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
A. Sánchez ◽  
L. R. Brun ◽  
H. Salerni ◽  
P. R. Costanzo ◽  
D. González ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Control Group ◽  
Bone Resorption Marker ◽  
Similar Response ◽  
Mineral Density ◽  
Turnover Markers

The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior. A control group of patients treated with BP not switched to Dmab matched by sex, age, and body mass index was used. Data are expressed as mean ± SEM. After 1 year of treatment with Dmab the bone formation markers total alkaline phosphatase and osteocalcin were significantly decreased (23.36% and 43.97%, resp.), as was the bone resorption marker s-CTX (69.61%). Significant increases in BMD were observed at the lumbar spine, femoral neck, and total hip without differences between BP-naïve and BP-prior. A better BMD response was found in BP-prior group compared with BP treated patients not switched to Dmab.Conclusion. Dmab treatment increased BMD and decreased bone turnover markers in the whole group, with similar response in BP-naïve and BP-prior patients. A better BMD response in BP-prior patients versus BP treated patients not switched to Dmab was observed.

scholarly journals Intravenous Zoledronic Acid 5 mg on Bone Turnover Markers and Bone Mineral Density in East China Subjects with Newly Diagnosed Osteoporosis: A 24-month Clinical Study

2017 ◽  
Vol 9 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Bo-cheng Liang ◽  
Zhen-yu Shi ◽  
Bo Wang ◽  
Peng Wu ◽  
Ling-cheng Kong ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Clinical Study ◽  
Zoledronic Acid ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
East China ◽  
Newly Diagnosed ◽  
Mineral Density ◽  
Turnover Markers
Sign in / Sign up

Export Citation Format

Share Document