Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys

2018 ◽  
Vol 37 (4) ◽  
pp. 636-647 ◽  
Author(s):  
Hiroyuki Yamada ◽  
Yasuo Ochi ◽  
Hiroshi Mori ◽  
Satoshi Nishikawa ◽  
Yasuaki Hashimoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Strength ◽  
Bone Mineral ◽  
Cathepsin K ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Cathepsin K Inhibitor ◽  
Cortical Bone Mineral Density

Efficacy of ONO-5334, a cathepsin K inhibitor, on bone turnover markers and bone mineral density in ovariectomized cynomolgus monkeys

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S70-S71 ◽  
Author(s):  
H. Yamada⁎ ◽  
H. Mori ◽  
A. Kunishige ◽  
S. Nishikawa ◽  
Y. Hashimoto ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Cathepsin K ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Cathepsin K Inhibitor ◽  
Turnover Markers

Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

2014 ◽  
Vol 54 (8) ◽  
pp. 937-948 ◽  
Author(s):  
Chihiro Hasegawa ◽  
Helen Kastrissios ◽  
Jonathan Monteleone ◽  
Tomoya Ohno ◽  
Takeo Umemura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Modeling And Simulation ◽  
Bone Mineral ◽  
Cathepsin K ◽  
Phase 2 ◽  
Mineral Density ◽  
Dose Selection ◽  
Cathepsin K Inhibitor ◽  
Phase 2 Study ◽  
Density Response

Regional differences in cortical bone mineral density in the weight-bearing long bone shaft—A pQCT study

Bone ◽  
2005 ◽  
Vol 36 (3) ◽  
pp. 465-471 ◽  
Author(s):  
Y.M. Lai ◽  
L. Qin ◽  
V.W.Y. Hung ◽  
K.M. Chan
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Regional Differences ◽  
Weight Bearing ◽  
Long Bone ◽  
Mineral Density ◽  
Cortical Bone Mineral Density

scholarly journals A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density

2019 ◽  
Vol 34 (7) ◽  
pp. 1306-1313 ◽  
Author(s):  
John P Kemp ◽  
Adrian Sayers ◽  
William D Fraser ◽  
George Davey Smith ◽  
Mika Ala‐Korpela ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Mineral Density ◽  
Cortical Bone Mineral Density

Minodronic acid (ONO-5920/YM529) prevents decrease in bone mineral density and bone strength, and improves bone microarchitecture in ovariectomized cynomolgus monkeys

Bone ◽  
2008 ◽  
Vol 43 (5) ◽  
pp. 840-848 ◽  
Author(s):  
Hiroshi Mori ◽  
Makoto Tanaka ◽  
Ryoji Kayasuga ◽  
Taisei Masuda ◽  
Yasuo Ochi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Strength ◽  
Bone Mineral ◽  
Bone Microarchitecture ◽  
Mineral Density ◽  
Cynomolgus Monkeys ◽  
Minodronic Acid

scholarly journals Genome-Wide Association Meta-Analysis of Cortical Bone Mineral Density Unravels Allelic Heterogeneity at the RANKL Locus and Potential Pleiotropic Effects on Bone

PLoS Genetics ◽  
2010 ◽  
Vol 6 (11) ◽  
pp. e1001217 ◽  
Author(s):  
Lavinia Paternoster ◽  
Mattias Lorentzon ◽  
Liesbeth Vandenput ◽  
Magnus K. Karlsson ◽  
Östen Ljunggren ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Meta Analysis ◽  
Pleiotropic Effects ◽  
Genome Wide Association ◽  
Allelic Heterogeneity ◽  
Mineral Density ◽  
Cortical Bone Mineral Density ◽  
Genome Wide

scholarly journals Cortical bone mineral density in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

2014 ◽  
Vol 82 (3) ◽  
pp. 330-337 ◽  
Author(s):  
Diala El-Maouche ◽  
Suzanne Collier ◽  
Mala Prasad ◽  
James C. Reynolds ◽  
Deborah P. Merke
Keyword(s):  
Bone Mineral Density ◽  
Congenital Adrenal Hyperplasia ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Adrenal Hyperplasia ◽  
Mineral Density ◽  
Hydroxylase Deficiency ◽  
Cortical Bone Mineral Density ◽  
21 Hydroxylase Deficiency

THU0473 Correlation between Metacarpal Cortical Bone Mineral Density Measured by Dual X-ray Densitometry and Radiogrammetry on Early Arthritis Patients:

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 363.2-363
Author(s):  
I. Llorente ◽  
L. Merino ◽  
A.M. Ortiz ◽  
S. González ◽  
E. Escolano ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cortical Bone ◽  
Bone Mineral ◽  
Early Arthritis ◽  
Mineral Density ◽  
X Ray ◽  
Cortical Bone Mineral Density
Sign in / Sign up

Export Citation Format

Share Document