Hemoconcentration is associated with early faster fluid rate and increased risk of persistent organ failure in acute pancreatitis patients

ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.ConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.

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SERUM ALBUMIN LEVEL IN PERSISTENT ORGAN FAILURE IN ACUTE PANCREATITIS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i5.232 ◽

2019 ◽

Vol 3 (5) ◽

Author(s):

Dr. Shefali Mehta ◽

Dr. Shuchi Goyal ◽

Dr. Rajendra Triloki ◽

Dr. A. K. Verma

Keyword(s):

Acute Pancreatitis ◽

Serum Albumin ◽

Organ Failure ◽

Serum Albumin Level ◽

Rapid Assessment ◽

Elevated Serum ◽

Albumin Level ◽

Persistent Organ Failure ◽

Increased Risk ◽

Patient Department

Introduction: The research emphasises on the association bond of Serum Albumin Level used as a marker for diagnosis of Persistent Organ Failure in Acute Pancreatitis. Material and Methods: The samples for the study were collected from the central lab, out-patient department and in-patient department of Department of Biochemistry, adult patients suffering from Acute Pancreatitis correlated to tropical medicinal stream and Gastroenterology Rabindranath Tagore Medical College, Udaipur, Rajasthan The research was carried out on a total of 100 patients for 1 year which were satisfying Atlanta criteria for Acute Pancreatitis will be diagnosed based on the following symptoms; elevated serum amylase, and lipase levels, that is greater than the normal limit, findings associated with the characteristics of the radiological findings. Also, with the abdominal computerized ultrasonography and tomography Results: In the present research, albumin always descends obviously in AP patients with POF (p < 0.05). The AUC under ROC line is 0.869. Albumin has been proved as an excellent marker of POF in AP. However, no previous study has researched into the association between albumin and incidence of POF in AP. Therefore, this study is the first time to show that the reduction of serum albumin is significantly associated with increased risk of POF in AP. Conclusion: Thus it can be concluded that serum albumin on admission is independently associated with POF in AP. The study suggests that albumin is a valuable tool for a rapid assessment of POF in patients with AP. Keywords: Serum Albumin, Persistent Organ Failure, Acute Pancreatitis

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