scholarly journals Tumor blood flow from arterial spin labeling perfusion MRI: A key parameter in distinguishing high-grade gliomas from primary cerebral lymphomas, and in predicting genetic biomarkers in high-grade gliomas

2013 ◽  
Vol 38 (4) ◽  
pp. 852-860 ◽  
Author(s):  
Roh-Eul Yoo ◽  
Seung Hong Choi ◽  
Hye Rim Cho ◽  
Tae Min Kim ◽  
Se-Hoon Lee ◽  
...  
Keyword(s):  
Blood Flow ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
High Grade ◽  
Tumor Blood Flow ◽  
Genetic Biomarkers ◽  
High Grade Gliomas ◽  
Key Parameter

scholarly journals Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuankai Lin ◽  
Jianrui Li ◽  
Zhiqiang Zhang ◽  
Qiang Xu ◽  
Zhenyu Zhou ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
White Matter ◽  
Mr Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Intravoxel Incoherent Motion ◽  
Low Grade ◽  
High Grade ◽  
Low Grade Gliomas ◽  
High Grade Gliomas

Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D∗), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated and then coregistered to generate the corresponding parameter values. We found CBF andD∗were higher in the high grade gliomas, whereas ADC,D, andfwere lower (allP<0.05). In differentiating the high from low grade gliomas, the maximum areas under the curves (AUC) ofD∗, CBF, and ADC were 0.857, 0.85, and 0.902, respectively. CBF was negatively correlated withfin tumor (r=-0.619,P=0.001). ADC was positively correlated withDin both tumor and white matter (r=0.887,P=0.000andr=0.824,P=0.000, resp.). There was no correlation between CBF andD∗in both tumor and white matter (P>0.05). IVIM DWI showed more efficiency than 3D pCASL but less validity than conventional DWI in differentiating the high from low grade gliomas.

scholarly journals Based on arterial spin labeling helps to differentiate high-grade gliomas from brain solitary metastasis

Medicine ◽  
2019 ◽  
Vol 98 (19) ◽  
pp. e15580
Author(s):  
Min Fu ◽  
Fang Han ◽  
Changchao Feng ◽  
Tao Chen ◽  
Xiaobo Feng
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
High Grade ◽  
Solitary Metastasis ◽  
High Grade Gliomas

P2-252: Cerebral blood flow changes in early Alzheimer's disease: A high-field arterial spin labeling perfusion MRI study

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P350-P350
Author(s):  
Xiaowei Song ◽  
Chen Wei ◽  
Ryan D'Arcy ◽  
Steven Beyea ◽  
Careesa Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
High Field ◽  
Spin Labeling ◽  
Perfusion Mri ◽  
Flow Changes ◽  
Early Alzheimer’S Disease ◽  
Mri Study

scholarly journals Arterial spin labeling in the grading of brain gliomas: could it help?

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Ahmed A. ElBeheiry ◽  
Doaa M. Emara ◽  
Amany Abdel-Bary Abdel-Latif ◽  
Mohamed Abbas ◽  
Amal S. Ismail
Keyword(s):  
Perfusion Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
High Morbidity ◽  
Low Grade ◽  
Dynamic Susceptibility ◽  
High Grade ◽  
Low Grade Gliomas ◽  
High Grade Gliomas ◽  
Brain Gliomas

Abstract Background Gliomas are characterized by high morbidity and mortality with low cure and high recurrence rates, which depends to a great degree on the angiogenesis of the tumor. Assessment of such angiogenesis by perfusion techniques is of utmost importance for the preoperative grading of gliomas. The purpose of this study was to assess the role of arterial spin labeling (ASL) perfusion as a non-contrast MRI technique in the grading of brain gliomas, in correlation with the dynamic susceptibility contrast perfusion imaging (DSC-PI). The study was carried out on 35 patients admitted to the Neurosurgery Department with MRI features of gliomas and sent for further perfusion imaging. Non-contrast ASL followed by DSC-PI was done for all cases. The final diagnosis of the cases was established by histopathology. Results Fourteen patients (14/35) had low-grade gliomas while twenty-one (21/35) had high-grade gliomas. In low-grade gliomas, four cases out of 14 were falsely graded as high-grade tumors showing hyperperfusion on ASL, three of which showed DSC-PI hypoperfusion. In high-grade gliomas, two cases out of 21 were interpreted as an indeterminate grade by ASL showing isoperfusion, however showed hyperperfusion on DSC-PI. ROC curve analysis showed ASL-derived rCBF > 2.08 to have 80.95% sensitivity, 85.71% specificity, and overall accuracy of 82.86% compared to 100% sensitivity, specificity, and accuracy of DSC-PI-derived rCBV and rCBF of > 1.1 and > 0.9, respectively. A significant positive correlation was noted between ASL and DSC-PI with correlation coefficient reaching r = 0.80 between ASL-rCBF and DSC-rCBF (p < 0.01) and r = 0.68 between ASL and DSC-rCBV (p < 0.01). Conclusions ASL is a relatively recent non-contrast perfusion technique that obtains results which are in fair agreement with the more established DSC perfusion imaging making it an alternative method for preoperative assessment of perfusion of gliomas, especially for patients with contraindications to contrast agents.

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