Characterization of an exception to the ‘even-electron rule’ upon low-energy collision induced decomposition in negative ion electrospray tandem mass spectrometry

2010 ◽  
Vol 45 (3) ◽  
pp. 235-240 ◽  
Author(s):  
Yang Cai ◽  
Zhenzhen Mo ◽  
Nalaka S. Rannulu ◽  
Bing Guan ◽  
Srinivasan Kannupal ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Low Energy ◽  
Negative Ion ◽  
Tandem Mass ◽  
Energy Collision ◽  
Electrospray Tandem Mass Spectrometry ◽  
Induced Decomposition

scholarly journals Electrospray Tandem Mass Spectrometry of 3'-azido-2',3'dideoxythymidine and of a Novel Series of 3'-azido-2',3',4'-trideoxy-4'thio-5-halogenouridines and their Respective α-Anomers

1994 ◽  
Vol 12 (2) ◽  
pp. 69-83 ◽  
Author(s):  
Joseph Banoub ◽  
Emmanuel Gentil ◽  
Bougrine Tber ◽  
Nour-Eddine Fahmi ◽  
Gino Ronco ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
Structural Characterization ◽  
Electrospray Mass Spectrometry ◽  
Low Energy ◽  
Tandem Mass ◽  
The Novel ◽  
Electrospray Tandem Mass Spectrometry ◽  
Protonated Molecules

Electrospray mass spectrometry has aided the structural characterization of 3'-azido-2',3'-dideoxythymidine (AZI) and the novel series of 3'-azido-2',3',4'trideoxy-4'-thio-S-(bromo, chi oro or fluoro )uridine nucleosides and their respective α.anomers. Low energy CAD MS/MS analysis of the protonated molecules [M+H]+confmned the predicted fragmentation route for AZT and a series of related 4'-thio-S-halogenouridines. This MSIMS study also provided characteristic fingerprint patterns which permitted differentiation of anomers within the series of 3'-azido-2' ,3' ,4' -trideoxy-4' -thio-S-halogenouridine nucleosides.

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