Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1

2003 ◽  
Vol 71 (5) ◽  
pp. 648-658 ◽  
Author(s):  
Hisanori Ito ◽  
Aki Nakajima ◽  
Hiroshi Nomoto ◽  
Shoei Furukawa
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Neural Stem Cells ◽  
Mrna Expression ◽  
Neuronal Differentiation ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

scholarly journals Nuclear export of OLIG2 in neural stem cells is essential for ciliary neurotrophic factor–induced astrocyte differentiation

2004 ◽  
Vol 166 (7) ◽  
pp. 963-968 ◽  
Author(s):  
Takao Setoguchi ◽  
Toru Kondo
Keyword(s):  
Stem Cells ◽  
Transcription Factors ◽  
Subventricular Zone ◽  
Nuclear Export ◽  
Ciliary Neurotrophic Factor ◽  
Extracellular Signals ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Astrocyte Differentiation ◽  
Oligodendrocyte Development

Neural stem cell (NSC) differentiation is precisely controlled by a network of transcription factors, which themselves are regulated by extracellular signals (Bertrand et al., 2002; Shirasakiand and Pfaff, 2002). One way that the activity of such transcription factors is controlled is by the regulation of their movement between the cytosol and nucleus (Vandromme et al., 1996. Lei and Silver, 2002). Here we show that the basic helix–loop–helix transcription factor OLIG2, which has been shown to be required for motor neuron and oligodendrocyte development, is found in the cytoplasm, but not the nucleus, of astrocytes in culture and of a subset of astrocytes in the subventricular zone. We demonstrate that the accumulation of OLIG2 in the nucleus of NSCs blocks the CNTF-induced astrocyte differentiation and that the translocation of OLIG2 to the cytoplasm is promoted by activated AKT. We propose that the AKT-stimulated export of OLIG2 from the nucleus of NSCs is essential for the astrocyte differentiation.

scholarly journals Roles of the Basic Helix-Loop-Helix GenesHes1andHes5in Expansion of Neural Stem Cells of the Developing Brain

2001 ◽  
Vol 276 (32) ◽  
pp. 30467-30474 ◽  
Author(s):  
Toshiyuki Ohtsuka ◽  
Masami Sakamoto ◽  
François Guillemot ◽  
Ryoichiro Kageyama
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Developing Brain ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix

scholarly journals Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation

Organogenesis ◽  
2014 ◽  
Vol 10 (4) ◽  
pp. 365-377 ◽  
Author(s):  
Leonardo D’Aiuto ◽  
Yun Zhi ◽  
Dhanjit Kumar Das ◽  
Madeleine R Wilcox ◽  
Jon W Johnson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Large Scale ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Human Ipsc
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