Protease-activated receptor subtype expression in developing eye and adult retina of the rat after optic nerve crush

2003 ◽  
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G. Reiser
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1982 ◽  
Vol 37 (11-12) ◽  
pp. 1274-1280 ◽  
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Roland Kästner ◽  
Hartwig Wolburg

Abstract Goldfish and carp are shown to be capable of functional reconstitution of the visual system, although their neural retina except of the marginal growth zone at the ora serrata was completely destroyed by injection of the Na-K-ATPase inhibitor ouabain. This was demonstrated by the observation of the recovery of the optokinetic nystagmus after dam age of the retina. Recovery of vision coincides well with the morphological reconstitution of the visual system. The regenerated axons within the optic nerve are still unmyelinated at the moment of visual recovery, whereas some fibers within the stratum opticum pars profunda of the corresponding optic tectum are already myelinated. The recovery of vision after regeneration of the retina was com pared with the recovery of vision after crush of the optic nerve. The range of time needed for visual recovery was smaller and better reproducible after crush than after dam age o f the retina.


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