Immunization with A91 peptide or copolymer-1 reduces the production of nitric oxide and inducible nitric oxide synthase gene expression after spinal cord injury

2011 ◽  
Vol 90 (3) ◽  
pp. 656-663 ◽  
Author(s):  
Elisa García ◽  
Raúl Silva-García ◽  
Humberto Mestre ◽  
Nayeli Flores ◽  
Susana Martiñón ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Cord Injury ◽  
Copolymer 1 ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals The Role of Inducible Nitric Oxide Synthase Following Spinal Cord Injury in Rat

2005 ◽  
Vol 20 (4) ◽  
pp. 663 ◽  
Author(s):  
Eun Kyoung Kwak ◽  
Jung Wan Kim ◽  
Ku Seong Kang ◽  
Yoon Hee Lee ◽  
Quan Hong Hua ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Cord Injury ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

scholarly journals Epidural Cooling Minimizes Spinal Cord Injury after Aortic Cross-clamping through Induction of Nitric Oxide Synthase

2009 ◽  
Vol 111 (4) ◽  
pp. 818-825 ◽  
Author(s):  
Akiko Ishikawa ◽  
Atsuo Mori ◽  
Nobuyuki Kabei ◽  
Akihiro Yoshitake ◽  
Takeshi Suzuki ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Blood Flow ◽  
Nitric Oxide Synthase ◽  
Cord Blood ◽  
Inducible Nitric Oxide Synthase ◽  
Spinal Cord Blood Flow ◽  
Cord Injury ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Background By using a U-shaped lumen catheter, the authors examined the effects of epidural cooling on spinal cord injury after aortic cross-clamping (ACC), with a focus on changes of spinal cord blood flow and expression of inducible nitric oxide synthase. Methods Sixteen pigs were randomized into two groups: Control group (n = 8) or Cooling group (n = 8). In the latter, epidural cooling started at 30 min (baseline) before 45 min of ACC and persisted for the next 30 min of reperfusion period. Spinal cord blood flow and somatosensory-evoked potentials were assessed during peri-ACC period. At 48 h, we evaluated hind limb function by using Tarlov score and expression of inducible nitric oxide synthase on spinal cord using immunohistochemistry. Results After ACC, spinal cord blood flow dropped to a similar extent in both groups. During the reperfusion period, spinal cord blood flow increased up to 113% (103-124%), median (interquartile range), level transiently and decreased to 32% (22-47%) level versus baseline in the Control group, whereas it increased and remained at 92% (86-97%) level in the Cooling group. Simultaneously, somatosensory-evoked potentials showed that onset of loss time was delayed and recovery time was shortened in the Cooling group. Tarlov scores in the Cooling group were significantly higher and accompanied by normal-appearing motor neurons and significantly greater expression of inducible nitric oxide synthase on spinal cord versus the Control group. Conclusions This study shows that epidural cooling during ACC minimized the risk of spinal cord injury, possibly by preventing delayed hypoperfusion and upregulating inducible nitric oxide synthase expression.

Beneficial effects of nitric oxide synthase inhibition on the recovery of neurological function after spinal cord injury in rats

2001 ◽  
Vol 363 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Toshio Suzuki ◽  
Hozumi Tatsuoka ◽  
Tanemichi Chiba ◽  
Toshihiko Sekikawa ◽  
Tetsuharu Nemoto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nitric Oxide Synthase ◽  
Neurological Function ◽  
Beneficial Effects ◽  
Cord Injury ◽  
Oxide Synthase
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