Regional expression of myelin protein genes in the developing mouse brain: In situ hybridization studies

1988 ◽  
Vol 21 (2-4) ◽  
pp. 238-248 ◽  
Author(s):  
A. N. Verity ◽  
A. T. Campagnoni
1996 ◽  
Vol 207 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Anna Maria Conti ◽  
Elio Scarpini ◽  
Maria Luisa Malosio ◽  
Anna Maria Di Giulio ◽  
Pierluigi Baron ◽  
...  

1990 ◽  
Vol 53 (1) ◽  
pp. 26-39 ◽  
Author(s):  
Caterina Bendotti ◽  
Christine Hohmann ◽  
Gianluigi Forloni ◽  
Roger Reeves ◽  
Joseph T. Coyle ◽  
...  

2011 ◽  
Vol 519 (10) ◽  
pp. 1867-1893 ◽  
Author(s):  
Stewart D. Clark ◽  
Dee M. Duangdao ◽  
Stefan Schulz ◽  
Li Zhang ◽  
Xiaobin Liu ◽  
...  

Blood ◽  
1989 ◽  
Vol 73 (1) ◽  
pp. 137-140
Author(s):  
WL Farrar ◽  
M Vinocour ◽  
JM Hill

The hematopoietic growth factor interleukin-3 (IL-3) promotes the proliferation and maturation of pluripotent myeloid progenitor cells. In the immune system, IL-3 is synthesized by mitogen or antigen- stimulated T lymphocytes. We demonstrate the expression of IL-3 mRNA in mouse brain by in situ hybridization histochemistry and Northern blot analysis. The IL-3 mRNA is localized in discrete areas of the brain and can be found in neuronal cell body and astrocytes. Northern analysis of cerebellar RNA, compared with mRNA extracted from WEHI-3 cells, showed a single hybridization band, approximately 1.2 kb, suggesting similar processing between brain and myeloid cells. The molecular evidence and previous observations of IL-3-like biologic activity found in the brain suggest a potential role for IL-3 in the neurobiology of the CNS.


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