scholarly journals Endothelial progenitor cells promote fracture healing in a segmental bone defect model

2010 ◽  
Vol 28 (8) ◽  
pp. 1007-1014 ◽  
Author(s):  
Kivanc Atesok ◽  
Ru Li ◽  
Duncan J. Stewart ◽  
Emil H. Schemitsch
Keyword(s):  
Fracture Healing ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Bone Defect ◽  
Segmental Bone Defect ◽  
Defect Model ◽  
Endothelial Progenitor ◽  
Segmental Bone

scholarly journals Engraftment of Prevascularized, Tissue Engineered Constructs in a Novel Rabbit Segmental Bone Defect Model

2015 ◽  
Vol 16 (12) ◽  
pp. 12616-12630 ◽  
Author(s):  
Alexandre Kaempfen ◽  
Atanas Todorov ◽  
Sinan Güven ◽  
René Largo ◽  
Claude Jaquiéry ◽  
...  
Keyword(s):  
Bone Defect ◽  
Segmental Bone Defect ◽  
Defect Model ◽  
Prevascularized Tissue ◽  
Segmental Bone

Dynamic compression promotes proliferation and neovascular networks of endothelial progenitor cells in demineralized bone matrix scaffold seed

2012 ◽  
Vol 113 (4) ◽  
pp. 619-626 ◽  
Author(s):  
Zhan Kong ◽  
Jianjun Li ◽  
Qun Zhao ◽  
Zhendong Zhou ◽  
Xiangnan Yuan ◽  
...  
Keyword(s):  
Fracture Healing ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Demineralized Bone Matrix ◽  
Dynamic Compression ◽  
Bone Matrix ◽  
Tube Formation ◽  
Endothelial Progenitor ◽  
Demineralized Bone

Neovascularization is required for bone formation and successful fracture healing. In the process of neovascularization, endothelial progenitor cells (EPCs) play an important role and finish vascular repair through reendothelialization to promote successful fracture healing. In this study, we found that dynamic compression can promote the proliferation and capillary-like tube formation of EPCs in the demineralized bone matrix (DBM) scaffold seed. EPCs isolated from the bone marrow of rats have been cultured in DBM scaffolds before dynamic compression and then seeded in the DBM scaffolds under dynamic conditions. The cells/scaffold constructs were subjected to cyclic compression with 5% strain and at 1 Hz for 4 h/day for 7 consecutive days. By using MTT and real-time PCR, we found that dynamic compression can significantly induce the proliferation of EPCs in three-dimensional culture with an even distribution of cells onto DBM scaffolds. Both in vitro and in vivo, the tube formation assays in the scaffolds showed that the loaded EPCs formed significant tube-like structures. These findings suggest that dynamic compression promoted the vasculogenic activities of EPCs seeded in the scaffolds, which would benefit large bone defect tissue engineering.

scholarly journals Determining the critical size of a rabbit rib segmental bone defect model

2016 ◽  
Vol 3 (5) ◽  
pp. 323-328 ◽  
Author(s):  
Fengzhen Liu ◽  
Kun Chen ◽  
Lei Hou ◽  
Keyi Li ◽  
Dawei Wang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Critical Size ◽  
Segmental Bone Defect ◽  
Defect Model ◽  
Segmental Bone

scholarly journals Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model

2015 ◽  
Vol 16 (4) ◽  
pp. 397 ◽  
Author(s):  
Daeyoung Yoon ◽  
Byung-Jae Kang ◽  
Yongsun Kim ◽  
Seung Hoon Lee ◽  
Daeun Rhew ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Bone Defect ◽  
Segmental Bone Defect ◽  
Defect Model ◽  
Segmental Bone

scholarly journals Significance of circulating endothelial progenitor cells in patients with fracture healing process

2012 ◽  
Vol 30 (11) ◽  
pp. 1860-1866 ◽  
Author(s):  
Xin-Long Ma ◽  
Xiao-Lei Sun ◽  
Chun-You Wan ◽  
Jian-Xiong Ma ◽  
Peng Tian
Keyword(s):  
Fracture Healing ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Healing Process ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells
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