scholarly journals Low-intensity ultrasound stimulation prevents osteoporotic bone loss in young adult ovariectomized mice

2010 ◽  
Vol 29 (1) ◽  
pp. 116-125 ◽  
Author(s):  
Dohyung Lim ◽  
Chang-Yong Ko ◽  
Dong Hyun Seo ◽  
Dae Gon Woo ◽  
Jin Man Kim ◽  
...  
Keyword(s):  
Young Adult ◽  
Bone Loss ◽  
Osteoporotic Bone ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Ovariectomized Mice ◽  
Low Intensity Ultrasound

Can ultrasound counteract bone loss? Effect of low-intensity ultrasound stimulation on a model of osteoclastic precursor

2007 ◽  
Vol 60 (4-7) ◽  
pp. 383-390 ◽  
Author(s):  
Monica Monici ◽  
Pietro Antonio Bernabei ◽  
Venere Basile ◽  
Giovanni Romano ◽  
Antonio Conti ◽  
...  
Keyword(s):  
Bone Loss ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Low Intensity Ultrasound ◽  
Loss Effect

Effects of Low Intensity Ultrasound Stimulation on the Proliferation of Alveolar Bone Marrow Stem Cells

2009 ◽  
Author(s):  
Eung Tae Lee ◽  
Ki Taek Lim ◽  
Chong Su Cho ◽  
Jang Ho Kim ◽  
Hyun Mok Son ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Alveolar Bone ◽  
Bone Marrow Stem Cells ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Low Intensity Ultrasound

scholarly journals Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss

2019 ◽  
Vol 5 (8) ◽  
pp. eaax1387 ◽  
Author(s):  
Yu-Ru V. Shih ◽  
Mengqian Liu ◽  
Seong Keun Kwon ◽  
Masayuki Iida ◽  
Ya Gong ◽  
...  
Keyword(s):  
Bone Loss ◽  
Adenosine Monophosphate ◽  
Osteoporotic Bone ◽  
Bone Homeostasis ◽  
Extracellular Adenosine ◽  
Ovariectomized Mice ◽  
A2b Receptor ◽  
Bona Fide ◽  
Membrane Bound ◽  
Cd73 Expression

Adenosine and its receptors play a key role in bone homeostasis and regeneration. Extracellular adenosine is generated from CD39 and CD73 activity in the cell membrane, through conversion of adenosine triphosphate to adenosine monophosphate (AMP) and AMP to adenosine, respectively. Despite the relevance of CD39/CD73 to bone health, the roles of these enzymes in bona fide skeletal disorders remain unknown. We demonstrate that CD39/CD73 expression and extracellular adenosine levels in the bone marrow are substantially decreased in animals with osteoporotic bone loss. Knockdown of estrogen receptors ESR1 and ESR2 in primary osteoprogenitors and osteoclasts undergoing differentiation showed decreased coexpression of membrane-bound CD39 and CD73 and lower extracellular adenosine. Targeting the adenosine A2B receptor using an agonist attenuated bone loss in ovariectomized mice. Together, these findings suggest a pathological association of purine metabolism with estrogen deficiency and highlight the potential of A2B receptor as a target to treat osteoporosis.

scholarly journals Scopolin Attenuates Osteoporotic Bone Loss in Ovariectomized Mice

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3565
Author(s):  
Eunkuk Park ◽  
Jeonghyun Kim ◽  
Hyun-Seok Jin ◽  
Chun Whan Choi ◽  
Tae Hyun Choi ◽  
...  
Keyword(s):  
Bone Loss ◽  
Osteoclast Differentiation ◽  
Bone Destruction ◽  
Osteoporotic Bone ◽  
Nodule Formation ◽  
Mineral Density ◽  
Bone Mineral Density Loss ◽  
Treatment And Prevention ◽  
Ovariectomized Mice ◽  
Bioactive Constituent

Bone remodeling is a renewal process regulated by bone synthesis (osteoblasts) and bone destruction (osteoclasts). A previous study demonstrated that Lycii radicis cortex (LRC) extract inhibited ovariectomized (OVX)-induced bone loss in mice. This study investigated the anti-osteoporotic effects of bioactive constituent(s) from the LRC extract. The effective compound(s) were screened, and a single compound, scopolin, which acts as a phytoalexin, was chosen as a candidate component. Scopolin treatment enhanced alkaline phosphatase activity and increased mineralized nodule formation in MC3T3-E1 pre-osteoblastic cells. However, osteoclast differentiation in primary-cultured monocytes was reduced by treatment with scopolin. Consistently, scopolin treatment increased osteoblast differentiation in the co-culture of monocytes (osteoclasts) and MC3T3-E1 (osteoblast) cells. Scopolin treatment prevented bone mineral density loss in OVX-induced osteoporotic mice. These results suggest that scopolin could be a therapeutic bioactive constituent for the treatment and prevention of osteoporosis.

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