scholarly journals mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats

2012 ◽  
Vol 31 (5) ◽  
pp. 724-730 ◽  
Author(s):  
Sunil K. Joshi ◽  
Xuhui Liu ◽  
Sanjum P. Samagh ◽  
David H. Lovett ◽  
Sue C. Bodine ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Nerve Injury ◽  
Rotator Cuff Tear ◽  
Fatty Infiltration ◽  
Suprascapular Nerve ◽  
Massive Rotator Cuff Tear ◽  
Cuff Tear

Histological analysis and biomechanical evaluation of fatty infiltration after rotator cuff tear and suprascapular nerve injury in a rat model

2018 ◽  
Vol 23 (5) ◽  
pp. 834-841
Author(s):  
Yu Sasaki ◽  
Nobuyasu Ochiai ◽  
Arata Nakajima ◽  
Takahisa Sasho ◽  
Tomonori Kenmoku ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Nerve Injury ◽  
Rotator Cuff Tear ◽  
Rat Model ◽  
Histological Analysis ◽  
Fatty Infiltration ◽  
Suprascapular Nerve ◽  
Cuff Tear ◽  
Biomechanical Evaluation

Influence of a nerve injury proximal to the suprascapular nerve on healing of repaired rotator cuff tear

2020 ◽  
Vol 25 (1) ◽  
pp. 96-103
Author(s):  
Koji Akimoto ◽  
Nobuyasu Ochiai ◽  
Eiko Hashimoto ◽  
Yasuhito Sasaki ◽  
Daisuke Nojima ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Nerve Injury ◽  
Rotator Cuff Tear ◽  
Suprascapular Nerve ◽  
Cuff Tear

scholarly journals Anterior Shoulder Dislocation with Massive Rotator Cuff tear and Axillary Nerve Injury - 4 Cases Report -

2004 ◽  
Vol 7 (2) ◽  
pp. 98-102
Author(s):  
Do-Yung Kim ◽  
Hyun-Chul Park ◽  
Yong-Wook Park ◽  
Sang-Soo Lee ◽  
Dong-Hyun Suh ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Nerve Injury ◽  
Rotator Cuff Tear ◽  
Shoulder Dislocation ◽  
Axillary Nerve ◽  
Anterior Shoulder Dislocation ◽  
Massive Rotator Cuff Tear ◽  
Cuff Tear

Biceps Detachment Preserves Joint Function in a Chronic Massive Rotator Cuff Tear Rat Model: Response

2019 ◽  
Vol 47 (5) ◽  
pp. NP34-NP35
Author(s):  
Mengcun Chen ◽  
Snehal S. Shetye ◽  
Julianne Huegel ◽  
Corinne N. Riggin ◽  
Daniel J. Gittings ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Rat Model ◽  
Joint Function ◽  
Massive Rotator Cuff Tear ◽  
Cuff Tear ◽  
Model Response

Retinoic Acid Receptor Agonists Suppress Muscle Fatty Infiltration in Mice

2021 ◽  
Vol 49 (2) ◽  
pp. 332-339
Author(s):  
Hideyuki Shirasawa ◽  
Noboru Matsumura ◽  
Masaki Yoda ◽  
Kazumasa Okubo ◽  
Masayuki Shimoda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Gene Expression Analysis ◽  
Retinoic Acid Receptor ◽  
Adipogenic Differentiation ◽  
Fatty Infiltration ◽  
Cuff Tear

Background: The infiltration of fat tissue into skeletal muscle, a condition referred to as muscle fatty infiltration or fatty degeneration, is regarded as an irreversible event that significantly compromises the motor function of skeletal muscle. Purpose: To investigate the effect of retinoic acid receptor (RAR) agonists in suppressing the adipogenic differentiation of fibroadipogenic progenitors (FAPs) in vitro and fatty infiltration after rotator cuff tear in mice. Study Design: Controlled laboratory study. Methods: FAPs isolated from mouse skeletal muscle were cultured in adipogenic differentiation medium in the presence or absence of an RAR agonist. At the end of cell culture, adipogenic differentiation was evaluated by gene expression analysis and oil red O staining. A mouse model of fatty infiltration—which includes the resection of the rotator cuff, removal of the humeral head, and denervation the supraspinatus muscle—was used to induce fatty infiltration in the supraspinatus muscle. The mice were orally or intramuscularly administered with an RAR agonist after the surgery. Muscle fatty infiltration was evaluated by histology and gene expression analysis. Results: RAR agonists effectively inhibited the adipogenic differentiation of FAPs in vitro. Oral and intramuscular administration of RAR agonists suppressed the development of muscle fatty infiltration in the mice after rotator cuff tear. In accordance, we found a significant decrease in the number of intramuscular fat cells and suppressed expression in adipogenic markers. RAR agonists also increased the expression of the transcripts for collagens; however, an accumulation of collagenous tissues was not histologically evident in the present model. Conclusion: Muscle fatty infiltration can be alleviated by RAR agonists through suppressing the adipogenic differentiation of FAPs. The results also suggest that RAR agonists are potential therapeutic agents for treating patients who are at risk of developing muscle fatty infiltration. The consequence of the increased expression of collagen transcripts by RAR agonists needs to be clarified. Clinical Relevance: RAR agonists can be used to prevent the development of muscle fatty infiltration after rotator cuff tear. Nevertheless, further studies are mandatory in a large animal model to examine the safety and efficacy of intramuscular injection of RAR agonists.

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