In Vivo Evaluation of a Biodegradable Donut-Shaped Minitablet for Prolonged Posterior Segment Drug Delivery in the Rabbit Eye Model

2011 ◽  
Vol 100 (5) ◽  
pp. 1819-1832 ◽  
Author(s):  
Yahya E. Choonara ◽  
Viness Pillay ◽  
Trevor R. Carmichael ◽  
Leith C.R. Meyer ◽  
Lisa C. Du Toit ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
In Vivo Evaluation ◽  
Eye Model ◽  
Rabbit Eye

Correction to: In Vivo Evaluation of a Biodegradable Donut-Shaped Minitablet for Prolonged Posterior Segment Drug Delivery in the Rabbit Eye Model. J Pharm Sci 100:1819–1832

2011 ◽  
Vol 100 (8) ◽  
pp. 3539
Author(s):  
Yahya E. Choonara ◽  
Viness Pillay ◽  
Michael P. Danckwerts ◽  
Trevor R. Carmichael ◽  
Leith C.R. Meyer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Posterior Segment ◽  
In Vivo Evaluation ◽  
Eye Model ◽  
Rabbit Eye

scholarly journals In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery

2020 ◽  
Vol 10 (5-s) ◽  
pp. 32-39
Author(s):  
Fatima Eram ◽  
, Vivek
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Average Concentration ◽  
Posterior Segment ◽  
Ocular Infection ◽  
In Vivo Evaluation ◽  
Micro Emulsion ◽  
In Situ Gelling

Objectives: The purpose of this research was to develop the micro emulsion-based in situ gelling systems containing Ciprofloxacin for prophylaxis and treatment of the posterior segment diseases like endophthalmitis. Methods: Ciprofloxacin was encapsulated in small droplets owing to form microemulsion, and then the formed droplets were dispersed in a polymer solution that converted into a gel upon triggered by the electrolyte present in the tear fluid. Results: The formulation approach provides better absorption, penetration, retention, and improves the bioavailability of the drug. The average concentration reached into vitreous humor from topical microemulsion in situ gelling formulation was ~0.4 µg/ml, which is far more than the concentration required for therapeutic effect (i.e.  >0.047 µg/ml or >MIC90 for S. Epidermidis, a pathogen commonly responsible to cause endophthalmitis). Conclusion: Thus, novel micro emulsion-based in situ gelling formulation could be a potential drug delivery system for the treatment of posterior segment diseases like endophthalmitis. Keywords: Microemulsion, ciprofloxacin, endophthalmitis, ocular, infection, in situ

Formulation, Characterization and In Vivo Evaluation of Self-Nanoemulsifying Drug Delivery System for Oral Delivery of Valsartan

2014 ◽  
Vol 10 (2) ◽  
pp. 263-270 ◽  
Author(s):  
Maulick Chopra ◽  
Usha Y. Nayak ◽  
Aravind Kumar Gurram ◽  
M. Sreenivasa Reddy ◽  
K.B. Koteshwara
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Delivery ◽  
In Vivo Evaluation

Design of 99mTc radiolabeled gemcitabine polymeric nanoparticles as drug delivery system and in vivo evaluation

2021 ◽  
Vol 263 ◽  
pp. 124380
Author(s):  
Çiğdem İçhedef ◽  
Serap Teksöz ◽  
Oğuz Çetin ◽  
Burcu Aydın ◽  
İbrahim Sarıkavak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Nanoparticles ◽  
In Vivo Evaluation

scholarly journals In vivo evaluation of a novel pH- and time-based multiunit colonic drug delivery system

2004 ◽  
Vol 20 (3) ◽  
pp. 347-353 ◽  
Author(s):  
C. Bott ◽  
M. W. Rudolph ◽  
A. R. J. Schneider ◽  
S. Schirrmacher ◽  
B. Skalsky ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Evaluation ◽  
Colonic Drug Delivery
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