A Hot-Melt Extruded Intravaginal Ring for the Sustained Delivery of the Antiretroviral Microbicide UC781

2012 ◽  
Vol 101 (2) ◽  
pp. 576-587 ◽  
Author(s):  
Meredith R. Clark ◽  
Todd J. Johnson ◽  
R. Tyler Mccabe ◽  
Justin T. Clark ◽  
Anthony Tuitupou ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring ◽  
Hot Melt

Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine

2011 ◽  
Vol 1 (3) ◽  
pp. 223-237 ◽  
Author(s):  
Manpreet Kaur ◽  
Kavita M. Gupta ◽  
Azadeh E. Poursaid ◽  
Prasoona Karra ◽  
Alamelu Mahalingam ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir

2012 ◽  
Vol 163 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Justin T. Clark ◽  
Todd J. Johnson ◽  
Meredith R. Clark ◽  
Joel S. Nebeker ◽  
Judit Fabian ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Sustained Delivery ◽  
Hydrophilic Matrix ◽  
Intravaginal Ring

Hot melt poly-ε-caprolactone/poloxamine implantable matrices for sustained delivery of ciprofloxacin

2012 ◽  
Vol 8 (4) ◽  
pp. 1507-1518 ◽  
Author(s):  
Ana M. Puga ◽  
Ana Rey-Rico ◽  
Beatriz Magariños ◽  
Carmen Alvarez-Lorenzo ◽  
Angel Concheiro
Keyword(s):  
Sustained Delivery ◽  
Hot Melt

scholarly journals An Intravaginal Ring for the Sustained Delivery of Antibodies

2014 ◽  
Vol 103 (11) ◽  
pp. 3611-3620 ◽  
Author(s):  
Manjula Gunawardana ◽  
Marc M. Baum ◽  
Thomas J. Smith ◽  
John A. Moss
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring

Development of hot-melt extruded drug/polymer matrices for sustained delivery of meloxicam

2022 ◽  
Author(s):  
Yun-Chu Chen ◽  
Dana E. Moseson ◽  
Coralie A. Richard ◽  
Monica R. Swinney ◽  
Sarena D. Horava ◽  
...  
Keyword(s):  
Polymer Matrices ◽  
Sustained Delivery ◽  
Hot Melt

scholarly journals Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

2013 ◽  
Vol 57 (8) ◽  
pp. 3994-3997 ◽  
Author(s):  
John A. Moss ◽  
Amanda M. Malone ◽  
Thomas J. Smith ◽  
Sean Kennedy ◽  
Cali Nguyen ◽  
...  
Keyword(s):  
Steady State ◽  
Sexually Transmitted Infections ◽  
Unintended Pregnancy ◽  
Sustained Delivery ◽  
Ovine Model ◽  
Sexually Transmitted ◽  
Intravaginal Rings ◽  
Wide Range ◽  
Intravaginal Ring ◽  
Proof Of Principle

ABSTRACTMultipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

scholarly journals An intravaginal ring for the sustained delivery of tenofovir disoproxil fumarate

2015 ◽  
Vol 495 (1) ◽  
pp. 579-587 ◽  
Author(s):  
Marc M. Baum ◽  
Irina Butkyavichene ◽  
Scott A. Churchman ◽  
Gilbert Lopez ◽  
Christine S. Miller ◽  
...  
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Sustained Delivery ◽  
Intravaginal Ring

Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

2009 ◽  
pp. 090624002829090
Author(s):  
Tristan P. Learoyd ◽  
Jane L. Burrows ◽  
Eddie French ◽  
Peter C. Seville
Keyword(s):  
Sustained Delivery ◽  
Double Emulsions ◽  
Spray Dried

Technological Advancements in Oral Films

2019 ◽  
Vol 9 (01) ◽  
pp. 15-20
Author(s):  
B Pandey ◽  
A B Khan
Keyword(s):  
3D Printing ◽  
Historical Background ◽  
Poorly Soluble Drugs ◽  
Modern Approach ◽  
Poorly Soluble ◽  
Critical Process Parameters ◽  
Biopharmaceutical Properties ◽  
Oral Films ◽  
Hot Melt ◽  
Modern Technologies

The aim of the review was to explore the necessity, advantages and different techniques of oral films for enhancing solubility of poorly soluble drugs with an emphasis on the newer, state-of the art technologies, such as 3D printing and hot-melt extrusion (HME). The historical background of oral films is presented along with the regularly used techniques. The modern approach of quality-by-design (QbD) is unravelled, identifying appropriate critical process parameters (CPP) and applied to oral films. A section is devoted modern technologies such as 3D printing and HME of oral films. Oral films are innovative formulations by which poorly soluble drugs have been founds to give positive results in enhancing their solubility and dissolution characteristics. With modern sophisticated techniques, precise mass production of oral films has been given a thrust. Oral films have better patient compliance, improved biopharmaceutical properties, improved efficacy, and better safety. By applying QbD and implementation of modern technologies the newer generation of oral films are yielding promising results

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