Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine

2011 ◽  
Vol 1 (3) ◽  
pp. 223-237 ◽  
Author(s):  
Manpreet Kaur ◽  
Kavita M. Gupta ◽  
Azadeh E. Poursaid ◽  
Prasoona Karra ◽  
Alamelu Mahalingam ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir

2012 ◽  
Vol 163 (2) ◽  
pp. 240-248 ◽  
Author(s):  
Justin T. Clark ◽  
Todd J. Johnson ◽  
Meredith R. Clark ◽  
Joel S. Nebeker ◽  
Judit Fabian ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Sustained Delivery ◽  
Hydrophilic Matrix ◽  
Intravaginal Ring

scholarly journals An Intravaginal Ring for the Sustained Delivery of Antibodies

2014 ◽  
Vol 103 (11) ◽  
pp. 3611-3620 ◽  
Author(s):  
Manjula Gunawardana ◽  
Marc M. Baum ◽  
Thomas J. Smith ◽  
John A. Moss
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring

scholarly journals Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

2013 ◽  
Vol 57 (8) ◽  
pp. 3994-3997 ◽  
Author(s):  
John A. Moss ◽  
Amanda M. Malone ◽  
Thomas J. Smith ◽  
Sean Kennedy ◽  
Cali Nguyen ◽  
...  
Keyword(s):  
Steady State ◽  
Sexually Transmitted Infections ◽  
Unintended Pregnancy ◽  
Sustained Delivery ◽  
Ovine Model ◽  
Sexually Transmitted ◽  
Intravaginal Rings ◽  
Wide Range ◽  
Intravaginal Ring ◽  
Proof Of Principle

ABSTRACTMultipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

scholarly journals An intravaginal ring for the sustained delivery of tenofovir disoproxil fumarate

2015 ◽  
Vol 495 (1) ◽  
pp. 579-587 ◽  
Author(s):  
Marc M. Baum ◽  
Irina Butkyavichene ◽  
Scott A. Churchman ◽  
Gilbert Lopez ◽  
Christine S. Miller ◽  
...  
Keyword(s):  
Tenofovir Disoproxil Fumarate ◽  
Sustained Delivery ◽  
Intravaginal Ring

A Hot-Melt Extruded Intravaginal Ring for the Sustained Delivery of the Antiretroviral Microbicide UC781

2012 ◽  
Vol 101 (2) ◽  
pp. 576-587 ◽  
Author(s):  
Meredith R. Clark ◽  
Todd J. Johnson ◽  
R. Tyler Mccabe ◽  
Justin T. Clark ◽  
Anthony Tuitupou ◽  
...  
Keyword(s):  
Sustained Delivery ◽  
Intravaginal Ring ◽  
Hot Melt

Sustained delivery of salbutamol and beclometasone from spray-dried double emulsions

2009 ◽  
pp. 090624002829090
Author(s):  
Tristan P. Learoyd ◽  
Jane L. Burrows ◽  
Eddie French ◽  
Peter C. Seville
Keyword(s):  
Sustained Delivery ◽  
Double Emulsions ◽  
Spray Dried

Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

2019 ◽  
Vol 9 (3) ◽  
pp. 248-263 ◽  
Author(s):  
Ashish K. Parashar ◽  
Preeti Patel ◽  
Arun K. Gupta ◽  
Neetesh K. Jain ◽  
Balak Das Kurmi
Keyword(s):  
Blood Glucose ◽  
Drug Release ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

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