Development of a Physiologically Based Pharmacokinetic Model for the Rat Central Nervous System and Determination of an In Vitro–In Vivo Scaling Methodology for the Blood–Brain Barrier Permeability of Two Transporter Substrates, Morphine and Oxycodone

Brain Barrier Permeability ◽

Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data

Drug Metabolism and Disposition ◽

10.1124/dmd.112.050294 ◽

2013 ◽

Vol 41 (4) ◽

pp. 744-753 ◽

Cited By ~ 15

Author(s):

Katherine L. Gill ◽

Michael Gertz ◽

J. Brian Houston ◽

Aleksandra Galetin

Keyword(s):

Pharmacokinetic Model ◽

Simulation of Toluene Kinetics in the Rat by a Physiologically Based Pharmacokinetic Model with Application of Biotransformation Parameters Derived Independently in Vitro and in Vivo

Toxicological Sciences ◽

10.1093/toxsci/32.2.260 ◽

1996 ◽

Vol 32 (2) ◽

pp. 260-268

Author(s):

JOOST DEJONGH ◽

BAS J. BLAAUBOER

Keyword(s):

Pharmacokinetic Model ◽

Development of a Physiologically Based Pharmacokinetic Model for Sinogliatin, a First-in-Class Glucokinase Activator, by Integrating Allometric Scaling, In Vitro to In Vivo Exploration and Steady-State Concentration–Mean Residence Time Methods: Mechanistic Understanding of its Pharmacokinetics

Clinical Pharmacokinetics ◽

10.1007/s40262-018-0631-z ◽

2018 ◽

Vol 57 (10) ◽

pp. 1307-1323 ◽

Cited By ~ 4

Author(s):

Ling Song ◽

Yi Zhang ◽

Ji Jiang ◽

Shuang Ren ◽

Li Chen ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Allometric Scaling ◽

Steady State Concentration ◽

Glucokinase Activator ◽

Physiologically Based ◽

State Concentration

Combining an In Vitro Kinetic Model with a Physiologically-Based Pharmacokinetic Model to Assess the Potential In Vivo Fate of Polyvinyl Pyrrolidone-Vinyl Acetate Copolymers

Pharmaceutical Research ◽

10.1007/s11095-017-2305-1 ◽

2018 ◽

Vol 35 (4) ◽

Author(s):

Daniel S. Hsieh ◽

Liang Luo ◽

Yan Xu ◽

Joshua D. Engstrom ◽

Qi Gao

Keyword(s):

Kinetic Model ◽

Vinyl Acetate ◽

Pharmacokinetic Model ◽

Polyvinyl Pyrrolidone ◽

Biopharmaceutic In Vitro In Vivo Extrapolation (IVIV_E) Informed Physiologically-Based Pharmacokinetic Model of Ritonavir Norvir Tablet Absorption in Humans Under Fasted and Fed State Conditions

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.0c00043 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2329-2344 ◽

Cited By ~ 4

Author(s):

Sumit Arora ◽

Amita Pansari ◽

Peter Kilford ◽

Masoud Jamei ◽

Iain Gardner ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Fed State ◽

Physiologically Based ◽

In Vivo Extrapolation

Physiologically Based Pharmacokinetic Model for Tetrachlorobenzyltoluenes in Rat: Comparison of in Vitro and in Vivo Metabolic Rates

Toxicological Sciences ◽

10.1093/toxsci/63.1.22 ◽

2001 ◽

Vol 63 (1) ◽

pp. 22-28 ◽

Cited By ~ 9

Author(s):

H. J. Kramer

Keyword(s):

Pharmacokinetic Model ◽

Metabolic Rates ◽

Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model

The Journal of Toxicological Sciences ◽

10.2131/jts.46.391 ◽

2021 ◽

Vol 46 (9) ◽

pp. 391-399

Author(s):

Mayu Yanagi ◽

Yusuke Kamiya ◽

Norie Murayama ◽

Kaito Banju ◽

Makiko Shimizu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

Pyrrolizidine Alkaloid ◽

Metabolic Profiles ◽

Data Sets ◽

Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

Pharmaceutics ◽

10.3390/pharmaceutics6010097 ◽

2014 ◽

Vol 6 (1) ◽

pp. 97-136 ◽

Cited By ~ 12

Author(s):

Raj Badhan ◽

Marylore Chenel ◽

Jeffrey Penny

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Pharmacokinetic Model ◽

The Novel In Vitro Method to Calculate Tissue-to-Plasma Partition Coefficient in Humans for Predicting Pharmacokinetic Profiles by Physiologically-Based Pharmacokinetic Model With High Predictability

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2020.04.002 ◽

2020 ◽

Vol 109 (7) ◽

pp. 2345-2355

Author(s):

Kei Mayumi ◽

Miho Tachibana ◽

Mei Yoshida ◽

Shuichi Ohnishi ◽

Takushi Kanazu ◽

...

Keyword(s):

Pharmacokinetic Model ◽

The Novel ◽

In Vitro Method ◽

Pharmacokinetic Profiles ◽

Physiologically Based ◽

High Predictability ◽

Plasma Partition Coefficient

Epimerization of moxalactam by albumin and simulation of in vivo epimerization by a physiologically based pharmacokinetic model

Chirality ◽

10.1002/(sici)1520-636x(1999)11:4<309::aid-chir8>3.0.co;2-g ◽

1999 ◽

Vol 11 (4) ◽

pp. 309-315 ◽

Cited By ~ 3

Author(s):

Takayoshi Yoshikawa ◽

Takayoshi Oguma ◽

Teruhisa Ichihashi ◽

Haruki Kinoshita ◽

Koichiro Hirano ◽

...

Keyword(s):

Pharmacokinetic Model ◽