A Novel Skeletal Drug-Delivery System Using Self-Setting Calcium Phosphate Cement. 4. Effects of the Mixing Solution Volume on the Drug-Release Rate of Heterogeneous Aspirin-Loaded Cement

1994 ◽  
Vol 83 (2) ◽  
pp. 259-263 ◽  
Author(s):  
Makoto Otsuka ◽  
Yoshihisa Matsuda ◽  
Yoshiko Suwa ◽  
Jeffrey L. Fox ◽  
William I. Higuchi
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Calcium Phosphate Cement ◽  
Drug Release Rate ◽  
Solution Volume

scholarly journals Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

RSC Advances ◽  
2017 ◽  
Vol 7 (84) ◽  
pp. 53401-53406 ◽  
Author(s):  
Ke Ma ◽  
Yiping Qiu ◽  
Yaqin Fu ◽  
Qing-Qing Ni
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Drug Release Rate ◽  
System P

Six kinds of nanoscale application are designed in this study. A significant increase of drug release rate can be observed at the gastric site.

scholarly journals FORMULATION AND EVALUATION OF SIMVASTATIN GASTRORETENTIVE DRUG DELIVERY SYSTEM

2017 ◽  
Vol 9 (3) ◽  
pp. 55
Author(s):  
Manjunath P. N. ◽  
Satish C. S. ◽  
Vasanti S. ◽  
Preetham A. C. ◽  
Naidu Ras
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Release Rate ◽  
Drug Transport ◽  
Hydroxypropyl Methylcellulose ◽  
In Vitro Dissolution ◽  
Dissolution Studies ◽  
Viscosity Grade

Objective: The aim of this study was to formulate and evaluate gastro retentive drug delivery system (GRRDS) using an effervescent approach for simvastatin.Methods: Floating tablets were prepared using directly compressible polymers hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M and carboxymethylcellulose sodium (NaCMC). The prepared tablets were subjected to pre-formulation studies like Compressibility index, Hausner ratio and post compression parameters like buoyancy/floating test and In vitro dissolution study.Results: Drug-excipient compatibility studies performed with the help of FTIR instrument indicated that there were no interactions. The DSC thermogram of the formulations revealed that crystalline form of simvastatin existed in the formulation which was confirmed by X-ray powder diffraction. Dissolution studies indicated that there was a decrease in the drug release with an increase in the polymer viscosity. The tablets prepared with low-viscosity grade HPMC K4M exhibited short Buoyancy Lag Time and floated for a longer duration as compared with formulations containing high viscosity grade HPMC K100M. The ‘n’ value for dissolution studies for all the formulations was found to be in the range of 0.647 to 0.975 indicating non-Fickian or anomalous drug transport. Conclusion: The drug release rate and floating duration of tablets depended on the nature of the polymer and other added excipients. The release rate of the drug can be optimized by using different ratios of polymers and other excipients. The formulation F8 achieved the optimized batch and complied with all the properties of the tablets.

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