Some Aspects of the Central Nervous System Activity of a Series of Urazole Derivatives**Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City

1959 ◽  
Vol 48 (2) ◽  
pp. 122-126 ◽  
Author(s):  
C.L. Mitchell ◽  
H.H. Keasling ◽  
E.G. Gross
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Iowa City ◽  
State University ◽  
University Of Iowa ◽  
System Activity ◽  
Nervous System Activity ◽  
Central Nervous System Activity ◽  
The Central Nervous System

Central nervous system active compounds. III. The synthesis of 4- and 6-substituted caprolactam derivatives by the Schmidt and Beckmann rearrangements

1980 ◽  
Vol 33 (11) ◽  
pp. 2477 ◽  
Author(s):  
GI Hutchison ◽  
RH Prager ◽  
AD Ward
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Beckmann Rearrangement ◽  
Active Compounds ◽  
System Activity ◽  
Nervous System Activity ◽  
Central Nervous System Activity ◽  
The Central Nervous System

The synthesis is described of hexahydroazepin-2-ones (caprolactams) bearing 1-4 alkyl or aryl groups at C4 and C6 by the Beckmann or Schmidt reactions on the corresponding cyclohex-2-enone. Further evidence for the mechanism of the Beckmann rearrangement of these unsaturated oximes is advanced. The central nervous system activity of the alkylated caprolactams is reported.

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