Development of core‐satellite‐shell structured MNP@Au@MIL‐100(Fe) substrates for surface‐enhanced Raman spectroscopy and their applications in trace level determination of malachite green in prawn

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.

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Dressing Plasmons in Nanoparticle-in-Quasi-Cavity Architectures for Trace-Level Surface-Enhanced Raman Spectroscopy Detection

ACS Applied Nano Materials ◽

10.1021/acsanm.0c02452 ◽

2021 ◽

Vol 4 (1) ◽

pp. 152-158

Author(s):

Maosen Yang ◽

Fengcai Lei ◽

Chundong Liu ◽

Jing Yu ◽

Jimmy C. Yu

Keyword(s):

Raman Spectroscopy ◽

Surface Enhanced Raman Spectroscopy ◽

Level Surface ◽

Trace Level ◽

Surface Enhanced ◽

Surface Enhanced Raman

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Detection of Triphenylmethane Drugs in Fish Muscle by Surface-Enhanced Raman Spectroscopy Coupled with Au-Ag Core-Shell Nanoparticles

Journal of Nanomaterials ◽

10.1155/2014/730915 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 18

Author(s):

Lu Pei ◽

Yiqun Huang ◽

Chunying Li ◽

Yuanyuan Zhang ◽

Barbara A. Rasco ◽

...

Keyword(s):

Raman Spectroscopy ◽

Malachite Green ◽

Crystal Violet ◽

Bimetallic Nanoparticles ◽

Limit Of Detection ◽

Fish Muscle ◽

Surface Enhanced Raman Spectroscopy ◽

Vis Spectroscopy ◽

Surface Enhanced ◽

Surface Enhanced Raman

Silver-coated gold bimetallic nanoparticles were synthesized and used as substrates for surface-enhanced Raman spectroscopy (SERS) in detecting prohibited triphenylmethane drugs (including crystal violet and malachite green) in fish muscle. The optical properties and physical properties of bimetallic nanospheres were characterized by UV-Vis spectroscopy and transmission electron microscopy. The optimal nanospheres selected had relatively uniform size (diameter: 33 ± 3 nm) with a silver layer coated on the surface of gold seed (diameter: 18 ± 2 nm). For both crystal violet and malachite green, characteristic SERS spectral features could be identified at concentration as low as 0.1 μg/L with these bimetallic nanospheres. Crystal violet and malachite green residues in fish muscle could also be detected at levels as low as 0.1 ng/g, which could meet the most restricted regulatory requirements for the limit of detection in terms of analytical methods for crystal violet or malachite green in fish muscle. This study provides a basis for applying SERS technology with bimetallic nanoparticles to the identification of trace amounts of prohibited substances in aquatic food products, and the methodology could be extended to analyses of other hazardous chemicals in complex food matrices like vegetables and meats.

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