Based on the kinematic model with Cartesian structure, Newton-Euler like algo¬rithm being employed to solve the nonlinear equations of motion and constraints in real-time application, and dynamic multibody simulation, a novel integrated design for a 6-DOF ro¬bot is investigated, and the interfaces required for the implementation of different computer aided engineering (CAE) tools used in the design is addressed [1].The presented method in this paper was analyzed and verified by the numerical and physical 6-DOF robot model, the result shows that the topologic projection me-thod [2] is stable. The design experience accumulated will be very useful for the future product de-sign.