Contrast CT-scan for preoperative planning of VSLN (vascularized submental lymph-node) transfer

2016 ◽  
Vol 115 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Damian Mullan ◽  
Damir Kosutic
Author(s):  
Raghav Sharma ◽  
Navneet Agarwal

<p class="abstract"><strong>Background: </strong>In oral cancer are 90% are squamous cell carcinomas (SCC) and lymphatic metastasis influences prognosis .With help of contrast CT scan finding done preoperatively and intraoperative finding during neck dissection we tried to generate a scoring system by which we can predict cervical lymph nodes metastasis systematically.</p><p class="abstract"><strong>Methods:</strong> Biopsy proven oral SCC cases underwent surgery between May 2012 to December 2018. Contrast enhanced computerized tomography (CECT) neck, intraoperative finding and post operative HPR (histopathology) were compared for the largest size node in the neck. Sensitivity, specificity, PPV, NPV and accuracy were calculated by using the hpr findings in the neck dissection specimen as control. Out of 68 cases, supraomohyoid neck dissection was done in 16 cases and radical neck dissection in 52 cases. Scores were put in Open Epi screening test software. Best cut off point was calculated using Youden Index.</p><p class="abstract"><strong>Results:</strong> Best cut off score (using Youden index and ROC curve) for CT scan was &gt;1 out of 7 features (size &gt;10 mm, central necrosis of lymph node, matting of lymph node, shape, extracapsular spread, vascular invasion, central hypodensity). Best cut off for intraoperative palpation was ≥3 out of 4 features (size, feel on palpation, adherence to surrounding structure, shape).</p><p class="abstract"><strong>Conclusions: </strong>Intraoperative findings can change the extent of surgery for being high sensitive and specific as compared to CT scan which is high sensitive but low specificity. A scoring system can be generated preoperative and intraoperatively to predict a node being malignant or not.</p><p class="abstract"> </p>


2005 ◽  
Vol 173 (4S) ◽  
pp. 432-432
Author(s):  
Georg C. Bartsch ◽  
Norbert Blumstein ◽  
Ludwig J. Rinnab ◽  
Richard E. Hautmann ◽  
Peter M. Messer ◽  
...  

1988 ◽  
Vol 24 (6) ◽  
pp. 994
Author(s):  
T S Chung ◽  
K M Kim ◽  
J H Suh ◽  
D I Kim ◽  
H J Jeong

2021 ◽  
pp. 849-853
Author(s):  
Charles J. Schneider ◽  
Michael Krainock ◽  
Allyson Koyen Malashevich ◽  
Meenakshi Malhotra ◽  
Perry Olshan ◽  
...  

Immunotherapy (IO) has increasingly been demonstrated to provide therapeutic benefit to patients with metastatic colorectal cancer (mCRC). However, only a subset of mCRC tumors respond to IO. Monitoring response with tumor biomarkers like carcinoembryonic antigen (CEA) has been challenging in patients with microsatellite stable (MSS) mCRC due to low expression of CEA (CEA/lo). Noninvasive blood-based biomarkers such as circulating tumor DNA (ctDNA) can inform early treatment response and augment radiographic monitoring. We describe a case study of a patient with chemotherapy-refractory CEA/lo MSS mCRC, with metastatic disease present in a cardiophrenic lymph node. The patient was given 2 cycles of combination IO (ipilimumab/nivolumab). Response was monitored by ctDNA using a multiplex PCR next-generation sequencing assay, CEA, and CT scan. After IO administration, ctDNA levels rapidly declined, becoming undetectable. This was concurrent with radiographic resolution of the lymph node metastasis. Serial monitoring of CEA during this same period was uninformative, with no significant changes observed. Significant decline in ctDNA identified metastatic response to IO in a patient with CEA/lo, MSS mCRC and was concurrently validated by CT scan. This case study provides evidence that ctDNA can be used as a prospective surrogate for radiographic tumor response.


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