The role of surgery after prolonged primary chemotherapy for advanced oesophageal adenocarcinoma

2021 ◽  
Author(s):  
Mohamed S. Aboul‐Enein ◽  
William Knight ◽  
Wahyu Wulaningsih ◽  
Daniel M. Foley ◽  
Dionysios Dellaportas ◽  
...  
Keyword(s):  
Primary Chemotherapy ◽  
Oesophageal Adenocarcinoma

Role of cyclooxygenase-2 in the development and treatment of oesophageal adenocarcinoma

2003 ◽  
Vol 38 (0) ◽  
pp. 87-93 ◽  
Author(s):  
C. J. Buskens ◽  
Ristimäki A. ◽  
G. J. A. Offerhaus ◽  
D. J. Richel ◽  
J. J. B. van Lanschot
Keyword(s):  
Cyclooxygenase 2 ◽  
Oesophageal Adenocarcinoma

Endodermal sinus tumor of the vagina the role of primary chemotherapy

Cancer ◽  
1985 ◽  
Vol 56 (5) ◽  
pp. 1025-1027 ◽  
Author(s):  
Willie A. Andersen ◽  
Hernan Sabio ◽  
Nancy Durso ◽  
Stacey E. Mills ◽  
Michael Levien ◽  
...  
Keyword(s):  
Primary Chemotherapy ◽  
Endodermal Sinus Tumor ◽  
Sinus Tumor

The role of primary chemotherapy for prostate cancer: Has the time come?

2006 ◽  
Vol 7 (3) ◽  
pp. 233-238
Author(s):  
P. Paula Hruska ◽  
Joel Picus
Keyword(s):  
Prostate Cancer ◽  
Primary Chemotherapy

An unusual presentation of synchronous bladder metastases from an oesophageal adenocarcinoma

2021 ◽  
Vol 103 (7) ◽  
pp. e227-e230
Author(s):  
D Wignall ◽  
R Sawant ◽  
A Gkentzis ◽  
L Lee
Keyword(s):  
Multidisciplinary Approach ◽  
Clinical Evidence ◽  
Oesophageal Carcinoma ◽  
Oesophageal Adenocarcinoma ◽  
Gastrointestinal Malignancy ◽  
Direct Invasion ◽  
Bladder Abnormalities ◽  
Upper Gastrointestinal ◽  
Progressive Dysphagia

Adenocarcinoma of the bladder is a rare form of malignancy accounting for fewer than 2% of bladder tumours. It is most commonly a result of direct invasion from prostatic, rectal or gynaecological primaries and less commonly presents from distant haematological or lymphatic metastasis. We report a rare case of oesophageal carcinoma metastasising to the bladder. It involves a 71-year-old man with progressive dysphagia and diagnostic computerised tomography findings of thickening in the oesophagus, bladder and common bile duct. Subsequent endoscopic biopsies of the oesophageal and bladder abnormalities showed immunohistochemical features consistent with upper gastrointestinal malignancy. This report aims to add to current clinical evidence of this route of metastasis and also highlight some of the key markers used by pathologists in interpretation of specimens. It also emphasises the essential role of a multidisciplinary approach for the diagnosis of such rare conditions.

scholarly journals Impact of Deoxycholic Acid on Oesophageal Adenocarcinoma Invasion: Effect on Matrix Metalloproteinases

2020 ◽  
Vol 21 (21) ◽  
pp. 8042
Author(s):  
Fran Quilty ◽  
Anne-Marie Byrne ◽  
John Aird ◽  
Sheeren El Mashad ◽  
Adolfo Parra-Blanco ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Deoxycholic Acid ◽  
Therapeutic Strategies ◽  
Oesophageal Adenocarcinoma ◽  
Low Concentrations ◽  
Cancer Invasiveness ◽  
Mrna And Protein Expression

Bile acids (BAs) have been implicated in the development of oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma (OAC). However, whether BAs promote cancer invasiveness has not been elucidated. We evaluated the role of BAs, in particular deoxycholic acid (DCA), in OAC invasion. Migration and invasiveness in untreated and BA-treated oesophageal SKGT-4 cancer cells were evaluated. Activity and expression of different matrix metalloproteinases (MMPs) were determined by zymography, ELISA, PCR and Western blot. Finally, human OAC tissues were stained for MMP-10 by immunohistochemistry. It was found that SKGT-4 cells incubated with low concentrations of DCA had a significant increase in invasion. In addition, MMP-10 mRNA and protein expression were also increased in the presence of DCA. MMP-10 was found to be highly expressed both in-vitro and in-vivo in neoplastic OAC cells relative to non-neoplastic squamous epithelial cells. Our results show that DCA promotes OAC invasion and MMP-10 overexpression. This study will advance our understanding of the pathophysiological mechanisms involved in human OAC and shows promise for the development of new therapeutic strategies.

The Role of Integrated F-18-FDG-PET Scanning in the Detection of M1 Disease in Oesophageal Adenocarcinoma and Impact on Clinical Management

2011 ◽  
Vol 15 (12) ◽  
pp. 2127-2135 ◽  
Author(s):  
Soumil Vyas ◽  
Sheraz R. Markar ◽  
Lydia Iordanidou ◽  
Samantha Read ◽  
David Stoker ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Clinical Management ◽  
Oesophageal Adenocarcinoma ◽  
Pet Scanning

492 POSTER Role of human epidermal receptor targeted therapies in chemo-sensitization of oesophageal adenocarcinoma cells

2008 ◽  
Vol 6 (12) ◽  
pp. 157
Author(s):  
L. Campbell ◽  
S. Van Schaeybroeck ◽  
J. Kyula ◽  
M.M. Eatock ◽  
P.G. Johnston
Keyword(s):  
Targeted Therapies ◽  
Oesophageal Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Human Epidermal Receptor

Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma

2012 ◽  
Vol 99 (3) ◽  
pp. 387-396 ◽  
Author(s):  
C. L. Donohoe ◽  
S. L. Doyle ◽  
S. McGarrigle ◽  
M. C. Cathcart ◽  
E. Daly ◽  
...  
Keyword(s):  
Growth Factor ◽  
Visceral Adiposity ◽  
Oesophageal Adenocarcinoma ◽  
Insulin Like Growth Factor

The role of primary chemotherapy for prostate cancer: Has the time come?

2006 ◽  
Vol 4 (4) ◽  
pp. 157-162
Author(s):  
P. Paula Hruska ◽  
Joel Picus
Keyword(s):  
Prostate Cancer ◽  
Primary Chemotherapy
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