Recurrence and survival after curative‐intent treatment for colorectal liver metastases: Implications for adjuvant liver‐directed regional chemotherapy

2021 ◽  
Author(s):  
Hordur M. Kolbeinsson ◽  
Allison Hoppe ◽  
Jessica Walker ◽  
Sreenivasa Chandana ◽  
M. Mura Assifi ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Regional Chemotherapy ◽  
Curative Intent

Prognosis of Synchronous Colorectal Liver Metastases After Simultaneous Curative-Intent Surgery According to Primary Tumor Location and KRAS Mutational Status

2020 ◽  
Vol 27 (13) ◽  
pp. 5150-5158 ◽  
Author(s):  
Ho Seung Kim ◽  
Jong Min Lee ◽  
Han Sang Kim ◽  
Seung Yoon Yang ◽  
Yoon Dae Han ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Primary Tumor ◽  
Colorectal Liver Metastases ◽  
Tumor Location ◽  
Curative Intent ◽  
Primary Tumor Location ◽  
Mutational Status ◽  
Synchronous Colorectal Liver Metastases

scholarly journals FIRST BRAZILIAN CONSENSUS ON MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 1: PRE-TREATMENT EVALUATION

2015 ◽  
Vol 28 (4) ◽  
pp. 222-230 ◽  
Author(s):  
Felipe José Fernandez COIMBRA ◽  
Heber Salvador de Castro RIBEIRO ◽  
Márcio Carmona MARQUES ◽  
Paulo HERMAN ◽  
Rubens CHOJNIAK ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Multimodal Treatment ◽  
Colorectal Liver Metastases ◽  
Epidemiological Data ◽  
Treatment Modalities ◽  
Established Method ◽  
Curative Intent ◽  
Pre Treatment ◽  
Definition Of

Background : Liver metastases of colorectal cancer are frequent and potentially fatal event in the evolution of patients with these tumors. Aim : In this module, was contextualized the clinical situations and parameterized epidemiological data and results of the various treatment modalities established. Method: Was realized deep discussion on detecting and staging metastatic colorectal cancer, as well as employment of imaging methods in the evaluation of response to instituted systemic therapy. Results : The next step was based on the definition of which patients would have their metastases considered resectable and how to expand the amount of patients elegible for modalities with curative intent. Conclusion : Were presented clinical, pathological and molecular prognostic factors, validated to be taken into account in clinical practice.

Curative-intent treatment of recurrent colorectal liver metastases: A comparison between ablation and resection

2017 ◽  
Vol 43 (10) ◽  
pp. 1901-1907 ◽  
Author(s):  
Aurélien Dupré ◽  
Robert P. Jones ◽  
Rafael Diaz-Nieto ◽  
Stephen W. Fenwick ◽  
Graeme J. Poston ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Curative Intent

Management of Hepatic Arterial Infusion Port Following Prophylactic Regional Chemotherapy in Patients who have Undergone Curative Resection of Colorectal Liver Metastases

Surgery Today ◽  
2003 ◽  
Vol 33 (9) ◽  
pp. 679-683 ◽  
Author(s):  
Takeshi Tono ◽  
Toshisada Ukei ◽  
Seizo Masutani ◽  
Kunitaka Shibata ◽  
Hiroki Ohzato ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Curative Resection ◽  
Hepatic Arterial Infusion ◽  
Regional Chemotherapy ◽  
Arterial Infusion

Management of symptomatic locoregional recurrence during regional chemotherapy for colorectal liver metastases

1998 ◽  
Vol 85 (3) ◽  
pp. 364-366
Author(s):  
Davies ◽  
Fordy ◽  
Burke ◽  
Allen-Mersh
Keyword(s):  
Liver Metastases ◽  
Locoregional Recurrence ◽  
Colorectal Liver Metastases ◽  
Regional Chemotherapy

The biodegradation of albumin microspheres used for regional chemotherapy in patients with colorectal liver metastases

1991 ◽  
Vol 12 (1) ◽  
pp. 57-64 ◽  
Author(s):  
J. A. GOLDBERG ◽  
N. S. WILLMOTT ◽  
J. H. ANDERSON ◽  
G. McCURRACH ◽  
R. G. BESSENT ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Regional Chemotherapy ◽  
Albumin Microspheres

scholarly journals The Prognostic Value of Preoperative Serum Lactate Dehydrogenase (LDH) Levels in Patients Underwent Curative-intent Hepatectomy For Colorectal Liver Metastases: A Two-Center Cohort Study

2021 ◽  
Author(s):  
Long Bai ◽  
Ze-Yu Lin ◽  
Yun-Xin Lu ◽  
Qin Chen ◽  
Han Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lactate Dehydrogenase ◽  
Liver Metastases ◽  
Peer Review ◽  
Cancer Patients ◽  
Prognostic Value ◽  
Colorectal Liver Metastases ◽  
Curative Intent ◽  
Preoperative Serum ◽  
Colorectal Cancer Patients

Abstract Background. The prognostic value of lactate dehydrogenase (LDH) in colorectal cancer patients has remained inconsistent between non-metastatic and metastatic settings. So far, very few studies have included LDH in the prognostic analysis of curative-intent surgery for colorectal liver metastases (CRLM).Patients and Methods. 580 consecutive metastatic colorectal cancer patients who underwent curative-intent CRLM resection from Blinded for peer review (434 patients) and Blinded for peer review (146 patients) treated in 2000-2019 were enrolled. Overall survival (OS) was the primary endpoint. Cox regression model was performed to identify the prognostic values of preoperative serum LDH levels and other clinicopathology variables. A modification of the established Fong CRS scoring system comprising LDH was developed within this Chinese population.Results. At the median follow-up time of 60.5 months, and median OS was 59.5 months in the pooled cohort. In the multivariate analysis, preoperative LDH > upper limit of normal (250 U/L) was the strongest independent prognostic factor for OS (HR 1.73, 95% confidence interval [CI], 1.22-2.44; P < .001). Patients with elevated LDH levels showed impaired OS than patients with normal LDH levels (27.6 months vs. 68.8 months). Five-year survival rates were 53.7% and 22.5% in the LDH-normal group and LDH-high group, respectively. Similar results were also confirmed in each cohort. In the subgroup analysis, LDH could distinguish the survival regardless of most established prognostic factors (number and size of CRLM, surgical margin, extrahepatic metastases, CEA and CA19-9 levels, etc.). Integrating LDH into the Fong score contributed to an improvement in the predictive value. Conclusion. Our study implicates serum LDH as a reliable and independent laboratory biomarker to predict the clinical outcome of curative-intent surgery for CRLM. Composite of LDH and Fong score is a potential stratification tool for CRLM resection. Prospective, international studies are needed to validate these results across diverse populations.

Curative-Intent Treatment for Colorectal Liver Metastases: A Medical Oncologist's Perspective

2012 ◽  
pp. 205-208 ◽  
Author(s):  
Leonard B. Saltz
Keyword(s):  
Liver Metastases ◽  
Patient Selection ◽  
Colorectal Liver Metastases ◽  
Curative Intent ◽  
Treatment Choices ◽  
Unresectable Disease ◽  
Realistic Assessment

Overview: Resection or ablation of CRC liver metastases can be offered with curative intent in some, but not all patients in whom resection is technically possible. Chemotherapy can improve the potential for cure to some degree, either in the adjuvant or neoadjuvant setting, or, in relatively rare circumstances, by converting truly unresectable disease into resectable. Careful and realistic patient selection, with an individualized and realistic assessment of curative potential, is key to providing each patient with the means to make realistic treatment choices.

Sign in / Sign up

Export Citation Format

Share Document