Assessment of Peripheral Nerves With Shear Wave Elastography in Type 1 Diabetic Adolescents Without Diabetic Peripheral Neuropathy

The article contains the review of literature data dedicated to the most common complication associated with diabetes mellitus (DM) - the diabetic peripheral neuropathy (DPN). DPN is regarded as economic burden for any state and significantly influences the quality of patient’s life. DPN is characterized by progressive degeneration of peripheral nerves that leads to pain syndrome, movement disorders and loss of sensation. There is a set of theories of development of DPN, but the major etiological factor is the chronic hyperglycemia. The article describes pathophysiologic mechanisms of DPN development. It is noted that considering high variability of clinical pattern DPN has no unified classification. The article addresses issues related to diagnostics and criteria of establishing the diagnosis. Special attention of the article is dedicated to pathogenic and expected treatment methods.

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Natural History of Corneal Nerve Morphology in Mild Neuropathy Associated With Type 1 Diabetes: Development of a Potential Measure of Diabetic Peripheral Neuropathy

Investigative Ophthalmology & Visual Science ◽

10.1167/iovs.14-15605 ◽

2014 ◽

Vol 55 (12) ◽

pp. 7982-7990 ◽

Cited By ~ 33

Author(s):

C. Dehghani ◽

N. Pritchard ◽

K. Edwards ◽

D. Vagenas ◽

A. W. Russell ◽

...

Keyword(s):

Type 1 Diabetes ◽

Peripheral Neuropathy ◽

Natural History ◽

Diabetic Peripheral Neuropathy ◽

History Of ◽

Diabetes Development ◽

Corneal Nerve ◽

Potential Measure ◽

Corneal Nerve Morphology

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Diabetic Peripheral Neuropathy and Urological Complications in Type 1 Diabetes: Findings From the Epidemiology of Diabetes Interventions and Complications Study

10.2337/figshare.16903747 ◽

2021 ◽

Author(s):

Rodica Pop-Busui ◽

Barbara H. Braffett ◽

Hunter Wessells ◽

William H. Herman ◽

Catherine L. Martin ◽

...

Keyword(s):

Type 1 Diabetes ◽

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Diabetes Duration ◽

Urinary Tract Symptoms ◽

Urological Complications ◽

Drinking Status ◽

Michigan Neuropathy Screening Instrument ◽

Diabetes Interventions

Objective: To evaluate associations between diabetic peripheral neuropathy (DPN) and urological complications in men and women with type 1 diabetes. ResearchDesignandMethods: Measurements of DPN at EDIC years 1, 13/14 and 17 and urological complications at EDIC year 17 were examined in 635 men (mean age 51.6 yrs, diabetes duration 29.5 yrs) and 371 women (mean age 50.6 yrs and diabetes duration 29.8 yrs) enrolled in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. DPN was defined by symptoms, signs and abnormal electrophysiology, or by abnormal Michigan Neuropathy Screening Instrument (MNSI) examination or questionnaire scores. Results: Erectile dysfunction (ED) in combination with lower urinary tract symptoms (LUTS) was reported in 15% of men, and female sexual dysfunction (FSD), LUTS and urinary incontinence (UI) in 16% of women. When controlling for age, drinking status, BMI, depression, DCCT/EDIC time-weighted mean HbA1c, microalbuminuria, hypertension, triglycerides and statin medication use, men with confirmed DPN at EDIC year 13/14 had a higher odds of ED/LUTS at year 17 compared to men without DPN (OR=3.52 95% CI 1.69,7.31). Men with DPN based on abnormal MNSI examination or questionnaire scores had significantly higher odds of ED and LUTS at year 17 than men without DPN at all time points. There were no significant differences in DPN between women reporting both FSD and LUTS/UI compared to those without FSD or LUTS/UI at EDIC year 17. Conclusions: In long-standing T1D, DPN is associated with the later development of urological complications in men.

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Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects

Medical Ultrasonography ◽

10.11152/mu-939 ◽

2017 ◽

Vol 19 (1) ◽

pp. 39 ◽

Cited By ~ 11

Author(s):

Mikail İnal ◽

Sinan Tan ◽

Erhan M. Yumusak ◽

Mehmet Hamdi Şahan ◽

Murat Alpua ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optic Nerve ◽

Healthy Volunteers ◽

Shear Wave ◽

Healthy Subjects ◽

Shear Wave Elastography ◽

Optic Nerves ◽

Type 3

Aims: Our aim was to evaluate the elasticity features of the optic nerve using strain (SE) and shear wave elastography (SWE) in multiple sclerosis (MS) patients in comparison with healthy subjects. Material and methods: One hundred and seven optic nerves from 54 MS patients and 118 optic nerves from 59 healthy subjects were examined prospectively by SE and SWE. Optic nerves were divided into three types in accordance to the elasticity designs, as follows: type 1 predominantly blue (hardest tissue); type 2 predominantly blue/green (hard tissue); and type 3 predominantly green (intermediate tissue). Quantitative measurements of optic nerve hardness with SWE were analyzed in kilopascals. Results: Elastographic images from healthy volunteers showed mostly type 3 optic nerves (61.9%); type 2 was also found (38.1%), but type 1 was not observed. Elastographic examination of MS patients showed mostly type 2 optic nerves (88%), while some type 1 (4.6%) and type 3 optic nerves (6.5%) were rarely observed. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p<0.001). Statistically significant differences were observed between patients and healthy volunteers in the analysis of SWE values (10.381±3.48 kPa and 33.87±11.64 p<0.001). The receiver operating characteristic curve analysis was perfect (0.993; 95% confidence interval [CI]=0.971–0.999), and a cut-off value of 18.3 kPa shear had very high sensitivity and specificity for the patient group. No significant differences were observed between patients with and without previous optic neuritis. Conclusion: SE and SWE examination findings concerning the optic nerve in MS patients demonstrated remarkable differences according to the healthy group.

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