Clinical characteristics and therapeutic response of objective tinnitus due to middle ear myoclonus: A large case series

2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Shi-Nae Park ◽  
Seong-Cheon Bae ◽  
Guen-Ho Lee ◽  
Jee-nam Song ◽  
Kyoung-Ho Park ◽  
...  
2020 ◽  
Vol 140 (7) ◽  
pp. 553-557
Author(s):  
Jung Mee Park ◽  
Woo Jin Kim ◽  
Jae Sang Han ◽  
So Young Park ◽  
Shi Nae Park

2021 ◽  
Author(s):  
Béatrice Garcin ◽  
Nicolas Villain ◽  
Francine Mesrati ◽  
Lionel Naccache ◽  
Emmanuel Roze ◽  
...  

AbstractFunctional motor disorders (FMD) are common and disabling. They are known to affect predominantly women and to start at young or middle age but to date, large case series are lacking, and demographic and clinical characteristics of patients with FMD rely on data from small cohorts. The current study aimed at describing the demographic and clinical characteristics of a large cohort of FMD patients.MethodsWe prospectively collected data from FMD patients who were referred to the Neurophysiology Department of the Pitié-Salpêtrière University Hospital between 2008 and 2016 for treatment with repeated transcranial magnetic stimulation.Results482 patients were included. There was a majority of women (73.7%) with a median age of 40 years old at TMS treatment. Median age at symptoms onset was 35.5 years old and symptoms were mostly characterized by an acute (47.3%) or subacute (46%) onset. Only 23% of patients were active workers while 58.3% were unemployed for medical reasons. Half of the patients suffered from functional motor weakness (n= 241) and the other half suffered from movement disorders (n=241), mainly represented by tremor (21.15%) and dystonia (20.5%). 33.6% had no psychiatric comorbidity and 17.4% reported no history of trauma. No significant differences were found in age or gender according to clinical phenotypes.ConclusionWe present the largest cohort of patients with FMD to date. This cohort will contribute to a better understanding of FMDs and their risk factors.


2021 ◽  
pp. 10.1212/CPJ.0000000000001078
Author(s):  
Yasmin Aghajan ◽  
Alison Yu ◽  
Caron A. Jacobson ◽  
Austin I. Kim ◽  
Leslie Kean ◽  
...  

Chimeric antigen receptor T (CART) cell therapy is highly effective for relapsed/refractory hematologic malignancy [1,2]; however, cytokine release syndrome (CRS) and neurotoxicity are observed in up to 77% of patients [3]. In large case series, the most common presentations of neurotoxicity were encephalopathy (57%), headache (42%), tremor (38%) and aphasia (35%). CART mediated spinal cord toxicity is not well characterized. Structural neurologic damage (stroke and intracranial hemorrhage) was only observed in 1-2% and seizures were seen in 1%-8% of cases [3, 4]. Neuroimaging findings in patients with neurotoxicity are rare and not specific.


2020 ◽  
Vol 95 (3) ◽  
pp. 181-187
Author(s):  
Han Hee Lee ◽  
Young-Seok Cho

Fecal microbiota transplantation (FMT), which has been established as the standard treatment for recurrent <i>Clostroides</i> difficile infection, may also play a role in the management of other diseases associated with dysbiosis of the gut microbiota. To ensure efficacy and safety of FMT, an appropriate donor screening process is required. The main purpose of donor screening is to check for infectious diseases that could be transmitted to the recipient. The screening process involves a medical history questionnaire, and blood and stool testing. Several randomized clinical trials and large case series on FMT reported no, or few, adverse events related to infection by following this donor screening process. However, there is still concern over the transmission of antibiotic-resistant bacteria. In addition, a low donor acceptance rate due to rigorous screening makes donor recruitment difficult, and also imposes a significant cost burden. A consensus on the most crucial elements of donor screening is needed for wide application of FMT.


2014 ◽  
Vol 42 (01) ◽  
pp. 13-19 ◽  
Author(s):  
B. D. Kruse ◽  
R. Müller ◽  
C. Stockhaus ◽  
K. Hartmann ◽  
A. Wehner ◽  
...  

Summary Objective: Measurement of rectal temperature is the most common method and considered gold standard for obtaining body temperature in dogs. So far, no study has been performed comparing agreement between rectal and auricular measurements in a large case series. The purpose of the study was to assess agreement between rectal and auricular temperature measurement in normothermic, hypothermic, and hyperthermic dogs with consideration of different environmental conditions and ear conformations. Materials and methods: Reference values for both methods were established using 62 healthy dogs. Three hundred dogs with various diseases (220 normothermic, 32 hypothermic, 48 hyperthermic) were enrolled in this prospective study. Rectal temperature was compared to auricular temperature and differences in agreement with regard to environmental temperature, relative humidity, and different ear conformations (pendulous versus prick ears) were evaluated using Pearson’s correlation coefficient and Bland-Altman analysis. Results: Correlation between rectal and auricular temperature was significant (r: 0.892; p < 0.01). However, Bland-Altman plots showed an inacceptable variation of values (bias: 0.300 °C; limits of agreement: –0.606 to 1.206 °C). This variation was above a maximal clinical tolerance of 0.3 °C, which was established by experts’ opinion (n = 16). Relative humidity had a significant influence (p = 0.001), whereas environmental temperature did not. Conclusion: Variation between the two methods of measuring body temperature was clinically unacceptable. Clinical relevance: Although measurement of auricular temperature is fast, simple, and well tolerated, this method provides a clinically unacceptable difference to the rectal measurement.


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