Age-related histologic and biochemical changes in auricular and septal cartilage

2017 ◽  
Vol 127 (11) ◽  
pp. E399-E407 ◽  
Author(s):  
Kiersten L. Riedler ◽  
Alireza Shokrani ◽  
Alexander Markarian ◽  
Laurel M. Fisher ◽  
Jon-Paul Pepper
Keyword(s):  
Septal Cartilage ◽  
Biochemical Changes ◽  
Age Related

scholarly journals Septoplasty in elderly patients

2020 ◽  
Vol 4 (4) ◽  
pp. 243-246
Author(s):  
S.A. Karpishchenko ◽  
◽  
G.V. Lavrenova ◽  
O.E. Vereshchagina ◽  
P.I. Gas’kova ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Donor Site ◽  
Management Strategies ◽  
Scoring Systems ◽  
Postoperative Management ◽  
Septal Cartilage ◽  
Elderly Persons ◽  
Nasal Breathing ◽  
Deviated Septum ◽  
Age Related

This review article attempts to systematize and summarize the data on the major age-related pathophysiological, biomechanical, and histological processes that contribute to the progression of nasal breathing impairment or the appearance of these symptoms in elderly patients. The specifics of risk assessment of deviated septum surgery using various questionnaires and scoring systems is discussed. The article demonstrates that deviated septum surgery can be performed in these patients and addresses the specificity of donor site selection for a septal graft in elderly patients considering the histological features of various septal cartilage regions. Prior assessment of individual risks is of particular importance since it determines surgical success and favorable postoperative course in these patients. Studies addressing the perspective use of tissue-engineering transplants are unraveled. Management strategies that consider aging biomechanisms potentially affecting treatment efficacy are described. Finally, the article highlights preoperative management, treatment choice, drug dosage regimens, and postoperative management after septoplasty. KEYWORDS: deviated septum, septoplasty, elderly persons, age-related disorders, neuromuscular tone, nasal breathing impairment. FOR CITATION: Karpishchenko S.A., Lavrenova G.V., Vereshchagina O.E., Gas’kova P.I. Septoplasty in elderly patients. Russian Medical Inquiry. 2020;4(4):243–246. DOI: 10.32364/2587-6821-2020-4-4-243-246.

scholarly journals Chronic adjunction of 1-deoxynojirimycin protects from age-related behavioral and biochemical changes in the SAMP8 mice

AGE ◽  
2015 ◽  
Vol 37 (5) ◽  
Author(s):  
Gui-Hai Chen ◽  
Jing-Jing Tong ◽  
Fang Wang ◽  
Xue-Qin Hu ◽  
Xue-Wei Li ◽  
...  
Keyword(s):  
Biochemical Changes ◽  
Age Related ◽  
Samp8 Mice

Effects of Chronic Irradiation on Age-Related Biochemical Changes in Mice

1983 ◽  
Vol 95 (3) ◽  
pp. 637 ◽  
Author(s):  
A. K. De ◽  
S. Chipalkatti ◽  
A. S. Aiyar
Keyword(s):  
Biochemical Changes ◽  
Chronic Irradiation ◽  
Age Related

scholarly journals Age-Related Changes in Human and Nonhuman Timing

2017 ◽  
Vol 5 (3-4) ◽  
pp. 261-279 ◽  
Author(s):  
Rannie Xu ◽  
Russell M. Church
Keyword(s):  
Time Perception ◽  
Cognitive Processing ◽  
Cognitive Aging ◽  
Comparative Research ◽  
Biochemical Changes ◽  
Age Related ◽  
Timing Ability ◽  
The Many ◽  
The Brain ◽  
Age Related Changes

The capacity for timed behavior is ubiquitous across the animal kingdom, making time perception an ideal topic of comparative research across human and nonhuman subjects. One of the many consequences of normal aging is a systematic decline in timing ability, often accompanied by a host of behavioral and biochemical changes in the brain. In this review, we describe some of these behavioral and biochemical changes in human and nonhuman subjects. Given the involvement of timing in higher-order cognitive processing, age-related changes in timing ability can act as a marker for cognitive decline in older adults. Finally, we offer a comparison between human and nonhuman timing through the perspective of Alzheimer’s disease. Taken together, we suggest that understanding timing functions and dysfunctions can improve theoretical accounts of cognitive aging and time perception, and the use of nonhuman subjects constitutes an integral part of this process.

Age-Related Alterations in Blood Biochemical Characterization of Hepatorenal Function in the PCK Rat

2015 ◽  
Vol 34 (6) ◽  
pp. 479-490 ◽  
Author(s):  
Yuichi Shimomura ◽  
William J. Brock ◽  
Yuko Ito ◽  
Katsumi Morishita
Keyword(s):  
Biochemical Characterization ◽  
Biochemical Changes ◽  
Large Individual ◽  
Progression Rate ◽  
Sprague Dawley ◽  
Blood Biochemical ◽  
Sd Rat ◽  
Age Related ◽  
Hepatorenal Function ◽  
Glutamyl Transpeptidase

PCK rats develop age-related polycystic kidney disease (PKD) and liver disease and have been used to investigate pharmacotherapies to ameliorate hepatorenal lesions for patients with PKD. The PCK rat may be useful to understand the possible susceptibility to hepatotoxicity observed in the patient with PKD having hepatic polycystic lesions. Therefore, the purpose of this study was to investigate the background blood biochemical changes that reflect the hepatorenal function of PCK rats as well as the terminal histopathology in order to determine whether this model would be suitable for extrapolating the susceptibility of hepatotoxicity in patients. The blood biochemical parameters of hepatorenal function and histopathology were investigated in PCK rats at ages 5 to 19 weeks and compared to those outcomes in the Sprague Dawley (SD) rat. There were notable blood biochemical changes possibly due to biliary dysgenesis in the PCK rat as early as 5 weeks of age. High levels of γ-glutamyl transpeptidase, alkaline phosphatase, alanine aminotransferase, and total bile acids persisted throughout the study compared to the SD rat. Increased aspartate aminotransferase, total bilirubin, and hyperlipidemia and a decrease in albumin were also evident at 10 to 19 weeks of age possibly due to progression of cholestatic liver dysfunction secondary to age-related liver cystic progression. Increased liver weights generally correlated with the severity of biliary and hepatic histopathological changes. In male PCK rats, age-related increases in blood urea nitrogen and creatinine at 10 to 19 weeks of age were observed, and the cystic progression was more severe than that in females. These data indicate that the PCK rat showed notable blood biochemical changes reflecting alteration of the liver function compared to the SD rat. Also, there was a large individual variation in these parameters possibly due to variable progression rate of biliary dysgenesis and subsequent liver damages in PCK rats.

The potential role of ozone in ameliorating the age-related biochemical changes in male rat cerebral cortex

2012 ◽  
Vol 13 (6) ◽  
pp. 565-581 ◽  
Author(s):  
Nagwa Ibrahim Shehata ◽  
Hanan Mohamed Abd-Elgawad ◽  
Mohamed Nabil Mawsouf ◽  
Amira Abd-Elmonem Shaheen
Keyword(s):  
Cerebral Cortex ◽  
Potential Role ◽  
Biochemical Changes ◽  
Rat Cerebral Cortex ◽  
Male Rat ◽  
Age Related

Chronic acarbose treatment alleviates age-related behavioral and biochemical changes in SAMP8 mice

2015 ◽  
Vol 284 ◽  
pp. 138-152 ◽  
Author(s):  
Jing-Jing Tong ◽  
Gui-Hai Chen ◽  
Fang Wang ◽  
Xue-Wei Li ◽  
Lei Cao ◽  
...  
Keyword(s):  
Biochemical Changes ◽  
Age Related ◽  
Acarbose Treatment ◽  
Samp8 Mice

Anterior Paraseptal Cartilage Development in Normal and Cleft Lip and Palate Human Fetal Specimens

1994 ◽  
Vol 31 (4) ◽  
pp. 339-345
Author(s):  
Mark P. Mooney ◽  
Michael I. Siegel ◽  
Kyle R. Kimes ◽  
John S. Todhunter ◽  
Timothy D. Smith
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Growth Curves ◽  
Septal Cartilage ◽  
Reconstruction Technique ◽  
Regression Equations ◽  
Cartilage Development ◽  
Age Related ◽  
Logarithmic Curve ◽  
Nasal Septal Cartilage

As part of an ongoing study of age-related variation in fetal cleft lip and palate nasal capsule morphology, anterior paraseptal cartilage development was examined histologically in a sample of nine complete cleft lip and palate human fetuses, and 20 without clefts ranging in age from 8 to 21 weeks. A computer reconstruction technique was used to quantify lengths, volumes, and generate growth curves from various regression equations. Anterior paraseptal cartilage length was seen to change in a slgmoldal fashion while volume changes were best described by a logarithmic curve for both groups, with the steepest increases from 15 to 21 weeks. Cleft specimens exhibited significantly different growth rates (line slopes) for both length and volume dimensions compared with the normal specimens. The larger, for age, cartilages were associated with an enlarged, Inferior border of the nasal septal cartilage and vomer in the cleft sample. These results are consonant with previous findings in this cleft fetal sample of other enlarged midline structures (i.e., nasal septal cartilage and vomer). Results suggest that growth abnormalities in one or all of these structures may be yet another mechanism for early nasal airway impingement and reduction in cleft lip and palate neonates.

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