Septal chondrocyte hypertrophy contributes to midface deformity in a mouse model of Apert syndrome

Midface hypoplasia is a major manifestation of Apert syndrome. However, the tissue component responsible for midface hypoplasia has not been elucidated. We studied mice with a chondrocyte-specific Fgfr2S252W mutation (Col2a1-cre; Fgfr2S252W/+) to investigate the effect of cartilaginous components in midface hypoplasia of Apert syndrome. In Col2a1-cre; Fgfr2S252W/+ mice, skull shape was normal at birth, but hypoplastic phenotypes became evident with age. General dimensional changes of mutant mice were comparable with those of mice with mutations in EIIa-cre; Fgfr2S252W/+, a classic model of Apert syndrome in mice. Col2a1-cre; Fgfr2S252W/+ mice showed some unique facial phenotypes, such as elevated nasion, abnormal fusion of the suture between the premaxilla and the vomer, and decreased perpendicular plate of the ethmoid bone volume, which are related to the development of the nasal septal cartilage. Morphological and histological examination revealed that the presence of increased septal chondrocyte hypertrophy and abnormal thickening of nasal septum is causally related to midface deformities in nasal septum-associated structures. Our results suggest that careful examination and surgical correction of the nasal septal cartilage may improve the prognosis in the surgical treatment of midface hypoplasia and respiratory problems in patients with Apert syndrome.

An unusual collection: Nasal septal abscess secondary to a Furuncle

Nasal septal abscess is an uncommon entity and most likely to occur with nasal septal hematoma associated with trauma. It occurs when pus collects between the mucoperichondrium and the nasal septal cartilage. Complications can be avoided by prompt identification and initiation of appropriate treatment. Thus avoiding systemic and cosmetic sequelae.We present a septal abscess secondary to nasal furuncle in a tertiary institute. This case report also serves to illustrate the investigations, recommended management and possible treatment outcomes.