scholarly journals Prognostic significance of regression and mitotic rate in head and neck cutaneous melanoma

2020 ◽  
Author(s):  
Elizabeth Kim ◽  
Isaac Obermeyer ◽  
Nathan Rubin ◽  
Samir S. Khariwala
Keyword(s):  
Head And Neck ◽  
Cutaneous Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate

Prognostic significance for metastasis of Ki-67 and mitotic rate in cutaneous melanoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7516-7516 ◽  
Author(s):  
P. A. Gimotty ◽  
P. Van Belle ◽  
D. E. Elder ◽  
K. Montone ◽  
T. Murry ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate ◽  
Ki 67

Prognostic significance for metastasis of Ki-67 and mitotic rate in cutaneous melanoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 7516-7516 ◽  
Author(s):  
P. A. Gimotty ◽  
P. Van Belle ◽  
D. E. Elder ◽  
K. Montone ◽  
T. Murry ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Prognostic Significance ◽  
Mitotic Rate ◽  
Ki 67

The Prognostic Significance of Circulating Tumour Cells in Head and Neck and Non-Small Cell Lung Cancer

2018 ◽  
Author(s):  
Arutha Kulasinghe ◽  
Joanna Kapeleris ◽  
Rebecca Kimberley ◽  
Stephen R Mattarollo ◽  
Erik W Thompson ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Head And Neck ◽  
Cell Lung Cancer ◽  
Prognostic Significance ◽  
Small Cell ◽  
Tumour Cells ◽  
Circulating Tumour Cells ◽  
Small Cell Lung

scholarly journals MO3-2 Prognostic significance of metastatic sites in recurrent or metastatic squamous cell carcinoma of the head and neck

2021 ◽  
Vol 32 ◽  
pp. S296
Author(s):  
Ari Nishimura ◽  
Tomoya Yokota ◽  
Yoshiyuki Iida ◽  
Tomoyuki Kamijo ◽  
Takashi Mukaigawa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Metastatic Squamous Cell Carcinoma ◽  
Metastatic Sites

scholarly journals CCL20/TNF/VEGFA Cytokine Secretory Phenotype of Tumor-Associated Macrophages Is a Negative Prognostic Factor in Cutaneous Melanoma

Cancers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 3943
Author(s):  
Alba Gutiérrez-Seijo ◽  
Elena García-Martínez ◽  
Celia Barrio-Alonso ◽  
Miriam Pareja-Malagón ◽  
Alejandra Acosta-Ocampo ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Large Fraction ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Rna Seq ◽  
Primary Cutaneous Melanoma ◽  
Kaplan Meier ◽  
Intracellular Cytokines ◽  
Negative Prognostic Factor

TAMs constitute a large fraction of infiltrating immune cells in melanoma tissues, but their significance for clinical outcomes remains unclear. We explored diverse TAM parameters in clinically relevant primary cutaneous melanoma samples, including density, location, size, and polarization marker expression; in addition, because cytokine production is a hallmark of macrophages function, we measured CCL20, TNF, and VEGFA intracellular cytokines by single-cell multiparametric confocal microscopy. The Kaplan–Meier method was used to analyze correlation with melanoma-specific disease-free survival and overall survival. No significant correlations with clinical parameters were observed for TAM density, morphology, or location. Significantly, higher contents of the intracellular cytokines CCL20, TNF, and VEGFA were quantified in TAMs infiltrating metastasizing compared to non-metastasizing skin primary melanomas (p < 0.001). To mechanistically explore cytokine up-regulation, we performed in vitro studies with melanoma-conditioned macrophages, using RNA-seq to explore involved pathways and specific inhibitors. We show that p53 and NF-κB coregulate CCL20, TNF, and VEGFA in melanoma-conditioned macrophages. These results delineate a clinically relevant pro-oncogenic cytokine profile of TAMs with prognostic significance in primary melanomas and point to the combined therapeutic targeting of NF-kB/p53 pathways to control the deviation of TAMs in melanoma.

scholarly journals Prognostic Significance of Epidermal Growth Factor Receptor Phosphorylation and Mutation in Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 14 (10) ◽  
pp. 1050-1050 ◽  
Author(s):  
Takanori Hama ◽  
Yuki Yuza ◽  
Yoshimichi Saito ◽  
Jin O‐uchi ◽  
Shu Kondo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Growth Factor Receptor ◽  
Epidermal Growth
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