Preparation, properties and complex formation ability of poly(ether-ester)s of poly(ethylene glycol)s and 2,6-pyridinedicarboxylic acid

1995 ◽  
Vol 196 (8) ◽  
pp. 2695-2708 ◽  
Author(s):  
Milena Ignatova ◽  
Nevena Manolova ◽  
Iliya Rashkov ◽  
Maurice Sepulchre ◽  
Nicolas Spassky
Keyword(s):  
Complex Formation ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Pyridinedicarboxylic Acid ◽  
Poly Ethylene ◽  
Ether Ester

Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice

2019 ◽  
Vol 14 (3) ◽  
pp. 280-291 ◽  
Author(s):  
Jaleh Varshosaz ◽  
Farshid Hassanzadeh ◽  
Batool Hashemi-Beni ◽  
Mohsen Minaiyan ◽  
Saeedeh Enteshari
Keyword(s):  
Side Effects ◽  
Antitumor Activity ◽  
Ethylene Glycol ◽  
Tissue Distribution ◽  
Tumor Cells ◽  
Maleic Acid ◽  
Polymeric Micelles ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Background: Due to the low water solubility of Docetaxel (DTX), it is formulated with ethanol and Tween 80 with lots of side effects. For this reason, special attention has been paid to formulate it in new drug nano-carriers. Objective: The goal of this study was to evaluate the safety, antitumor activity and tissue distribution of the novel synthesized Raloxifene (RA) targeted polymeric micelles. Methods: DTX-loaded RA-targeted polymeric micelles composed of poly(styrene-maleic acid)- poly(amide-ether-ester-imide)-poly(ethylene glycol) (SMA-PAEE-PEG) were prepared and their antitumor activity was studied in MC4-L2 tumor-bearing mice compared with non-targeted micelles and free DTX. Safety of the micelles was studied by Hematoxylin and Eosin (H&E) staining of tumors and major organs of the mice. The drug accumulation in the tumor and major organs was measured by HPLC method. Results: The results showed better tumor growth inhibition and increased survival of mice treated with DTX-loaded in targeted micelles compared to the non-targeted micelles and free DTX. Histopathological studies, H&E staining of tumors and immunohistochemical examination showed the potential of DTX-loaded RA-targeted micelles to inhibit tumor cells proliferation. The higher accumulation of the DTX in the tumor tissue after injection of the micelles compared to the free DTX may indicate the higher uptake of the targeted micelles by the G-Protein-Coupled Estrogen Receptors (GPER). Conclusion: The results indicate that RA-conjugated polymeric micelles may be a strong and effective drug delivery system for DTX therapy and uptake of the drug into tumor cells, and overcome the disadvantages and side effects of conventional DTX.

In vivo and in vitro degradation of poly(ether ester) block copolymers based on poly(ethylene glycol) and poly(butylene terephthalate)

Biomaterials ◽  
2004 ◽  
Vol 25 (2) ◽  
pp. 247-258 ◽  
Author(s):  
A.A. Deschamps ◽  
A.A. van Apeldoorn ◽  
H. Hayen ◽  
J.D. de Bruijn ◽  
U. Karst ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Vitro Degradation ◽  
Butylene Terephthalate ◽  
Poly Ethylene ◽  
Ether Ester

Effects of Poly(Ethylene Glycol) Segment on Physical and Chemical Properties of Poly(Ether Ester) Elastomers

2017 ◽  
Vol 898 ◽  
pp. 2147-2157 ◽  
Author(s):  
Qiu Shu Xu ◽  
Lian Tang ◽  
Chao Sheng Wang ◽  
Biao Wang ◽  
Hua Ping Wang
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Impact Resistance ◽  
Chemical Properties ◽  
Weight Ratio ◽  
Soxhlet Extraction ◽  
Polymerization Process ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Ether Ester

Poly (ether ester) elastomer, a segmented copolymer, recently has attracted a wide attention for its unique properties such as elasticity, low temperature impact resistance and chemistry resistance. In this work, a range of poly (ether ester) s were synthesized via a two-step polymerization method using poly (ethylene terephthalate) (PET) as rigid segment and poly (ethylene glycol) (PEG) as flexible segment. The effects of the molecular weight (1000-8000 g/mol) and the weight ratios with PEG (30/100-70/100) of PET segments on the performance of synthetic copolymers were investigated. The chemical structure, thermal properties and hydrophilic performance of the copolymers were respectively characterized. Additionally, the practical block ratios of PEG/PET were calculated by the 1H-NMR Spectra of the copolymer after Soxhlet extraction. Through the obtained results, it revealed that increasing the molecular weight or content of PEG could enhance the hydrophilic performance of the copolymers and reversely reduce its thermal stability. It was shown that the reactivity of PEG in the polymerization process was weakened when its molecular weight was above 4000 or weight ratio with PTA was higher than 60/100, subsequently affected the practical block ratios of PEG/PET in the resulting poly(ether ester)elastomers.

Autonomous viscosity oscillation by reversible complex formation of terpyridine-terminated poly(ethylene glycol) in the BZ reaction

Soft Matter ◽  
2010 ◽  
Vol 6 (24) ◽  
pp. 6072 ◽  
Author(s):  
Tomonaga Ueno ◽  
Kaori Bundo ◽  
Yuki Akagi ◽  
Takamasa Sakai ◽  
Ryo Yoshida
Keyword(s):  
Complex Formation ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Bz Reaction ◽  
Poly Ethylene
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