Competitors' envy, gamers' pride: An exploration of gamers' divergent behavior

2021 ◽  
Author(s):  
Rashmini Sharma ◽  
Gurmeet Singh ◽  
Shavneet Sharma
Keyword(s):  

Author(s):  
Héctor López-Mendoza ◽  
Antonio Montañés ◽  
Franciso Javier Moliner-Lahoz

Spain experienced a second wave of the COVID-19 pandemic in autumn 2020, which has been approached with different measures by regional authorities. We analyze the presence of convergence in the cumulative incidence for 14 days (CI14) in provinces and self-governing cities. The Phillips–Sul methodology was used to study the grouping of behavior between provinces, and an ordered logit model was estimated to understand the forces that drive creating the different convergence clubs. We reject the presence of a single pattern of behavior in the evolution of the CI14 across territories. Four statistically different convergence clubs and an additional province (Madrid) with divergent behavior are observed. Provinces with developed agricultural and industrial economic sectors, high mobility, and a high proportion of Central and South American immigrants had the highest level of CI14. We show that the transmission of the virus is not homogeneous in the Spanish national territory. Our results are helpful for identifying differences in determinants that could explain the pandemic’s evolution and for formulating hypotheses about the effectiveness of implemented measures.



2015 ◽  
Vol 17 (suppl 3) ◽  
pp. iii36-iii36
Author(s):  
O. R. Lindberg ◽  
A. McKinney ◽  
J. R. Engler ◽  
J. J. Phillips


1999 ◽  
Vol 14 (13) ◽  
pp. 2103-2115 ◽  
Author(s):  
BISWANATH RATH

We study the divergent behavior of the Morse–Feshbach nonlinear perturbation series (MFNS) [P. M. Morse and H. Feshbach, Methods of Theoretical Physics, Part II (McGraw-Hill, New York, 1953)] for producing convergent energy levels using the ground state of a quartic anharmonic oscillator (AHO) in the strong coupling limit. Numerical calculations have been done up to tenth order. Further comparison of the MFNS convergent result has been made with the matrix diagonalization method.



2018 ◽  
Vol 93 (2) ◽  
Author(s):  
Romain Appourchaux ◽  
Mathilde Delpeuch ◽  
Li Zhong ◽  
Julien Burlaud-Gaillard ◽  
Kevin Tartour ◽  
...  

ABSTRACT The interferon-induced transmembrane proteins (IFITMs) are a family of highly related antiviral factors that affect numerous viruses at two steps: in target cells by sequestering incoming viruses in endosomes and in producing cells by leading to the production of virions that package IFITMs and exhibit decreased infectivity. While most studies have focused on the former, little is known about the regulation of the negative imprinting of virion particle infectivity by IFITMs and about its relationship with target cell protection. Using a panel of IFITM3 mutants against HIV-1, we have explored these issues as well as others related to the biology of IFITM3, in particular virion packaging, stability, the relation to CD63/multivesicular bodies (MVBs), the modulation of cholesterol levels, and the relationship between negative imprinting of virions and target cell protection. The results that we have obtained exclude a role for cholesterol and indicate that CD63 accumulation does not directly relate to an antiviral behavior. We have defined regions that modulate the two antiviral properties of IFITM3 as well as novel domains that modulate protein stability and that, in so doing, influence the extent of its packaging into virions. The results that we have obtained, however, indicate that, even in the context of an IFITM-susceptible virus, IFITM3 packaging is not sufficient for negative imprinting. Finally, while most mutations concomitantly affect target cell protection and negative imprinting, a region in the C-terminal domain (CTD) exhibits a differential behavior, potentially highlighting the regulatory role that this domain may play in the two antiviral activities of IFITM3. IMPORTANCE IFITM proteins have been associated with the sequestration of incoming virions in endosomes (target cell protection) and with the production of virion particles that incorporate IFITMs and exhibit decreased infectivity (negative imprinting of virion infectivity). How the latter is regulated and whether these two antiviral properties are related remain unknown. By examining the behavior of a large panel of IFITM3 mutants against HIV-1, we determined that IFITM3 mutants are essentially packaged into virions proportionally to their intracellular levels of expression. However, even in the context of an IFITM-susceptible virus, IFITM3 packaging is not sufficient for the antiviral effects. Most mutations were found to concomitantly affect both antiviral properties of IFITM3, but one CTD mutant exhibited a divergent behavior, possibly highlighting a novel regulatory role for this domain. These findings thus advance our comprehension of how this class of broad antiviral restriction factors acts.







2019 ◽  
Vol 2 (4) ◽  
pp. 212-214
Author(s):  
Ichiro Tsuboi ◽  
Yuki Maruyama ◽  
Takuya Sadahira ◽  
Koichiro Wada ◽  
Nobuyoshi Ando ◽  
...  




1999 ◽  
Vol 40 (24) ◽  
pp. 4563-4566 ◽  
Author(s):  
Mitsuru Kitamura ◽  
Ken Ohmori ◽  
Keisuke Suzuki


2007 ◽  
Vol 26 (14) ◽  
pp. 3541-3551 ◽  
Author(s):  
David Aguilar ◽  
Miguel Angel Aragüés ◽  
Raquel Bielsa ◽  
Elena Serrano ◽  
Rafael Navarro ◽  
...  


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