scholarly journals CSF Protein Level of Neurotransmitter Secretion, Synaptic Plasticity, and Autophagy in PD and DLB

2021 ◽  
Author(s):  
Stefanie Lerche ◽  
Simon Sjödin ◽  
Ann Brinkmalm ◽  
Kaj Blennow ◽  
Isabel Wurster ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Protein Level ◽  
Neurotransmitter Secretion

scholarly journals Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid

2021 ◽  
Vol 22 (6) ◽  
pp. 3209
Author(s):  
Magdalena Gąssowska-Dobrowolska ◽  
Agnieszka Kolasa-Wołosiuk ◽  
Magdalena Cieślik ◽  
Agnieszka Dominiak ◽  
Kristina Friedland ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cerebral Cortex ◽  
Synaptic Plasticity ◽  
Tau Protein ◽  
Dendritic Spine ◽  
Protein Level ◽  
Autism Spectrum ◽  
Spine Density ◽  
Phosphorylation State ◽  
Β Tubulin

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology associated with synaptic plasticity disturbances. Since microtubules (MTs) regulate dendritic spine morphology and play an important role in spine development and plasticity the aim of the present study was to investigate the alterations in the content of neuronal α/β-tubulin and Tau protein level as well as phosphorylation state in the valproic acid (VPA)-induced rat model of autism. Our results indicated that maternal exposure to VPA induces: (1) decrease the level of α/β-tubulin along with Tau accumulation in the hippocampus and cerebral cortex; (2) excessive Tau phosphorylation and activation of Tau-kinases: CDK5, ERK1/2, and p70S6K in the cerebral cortex; (3) up-regulation of mTOR kinase-dependent signalling in the hippocampus and cerebral cortex of adolescent rat offspring. Moreover, immunohistochemical staining showed histopathological changes in neurons (chromatolysis) in both analysed brain structures of rats prenatally exposed to VPA. The observed changes in Tau protein together with an excessive decrease in α/β-tubulin level may suggest destabilization and thus dysfunction of the MT cytoskeleton network, which in consequence may lead to the disturbance in synaptic plasticity and the development of autistic-like behaviours.

Synaptic plasticity of striatal cholinergic interneurons

2000 ◽  
Vol 38 ◽  
pp. S95
Author(s):  
T Suzuki
Keyword(s):  
Synaptic Plasticity ◽  
Cholinergic Interneurons

A four day course of Lovastatin improves synaptic plasticity in patients with NF-1

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
F Mainberger ◽  
N Jung ◽  
M Zenker ◽  
I Delvendahl ◽  
U Wahlländer-Danek ◽  
...  
Keyword(s):  
Synaptic Plasticity

Modulation of Ca2+ currents and long-term synaptic plasticity by SSRIs

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
C Normann
Keyword(s):  
Synaptic Plasticity
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