In vitro andin vivo evaluation of anticancer actions of natural and synthetic vitamin E forms

2008 ◽  
Vol 52 (4) ◽  
pp. 447-456 ◽  
Author(s):  
Weiping Yu ◽  
Li Jia ◽  
Pei Wang ◽  
Karla A. Lawson ◽  
Marla Simmons-Menchaca ◽  
...  
Keyword(s):  
Vitamin E ◽  
Synthetic Vitamin ◽  
Natural And Synthetic

Relative Bioavailabilities of Natural and Synthetic Vitamin E Formulations Containing Mixed Tocopherols in Human Subjects

1999 ◽  
Vol 69 (2) ◽  
pp. 92-95 ◽  
Author(s):  
Chopra ◽  
Bhagavan
Keyword(s):  
Vitamin E ◽  
Animal Models ◽  
Human Subjects ◽  
Alpha Tocopherol ◽  
Tocopheryl Acetate ◽  
Normal Male ◽  
Gamma Tocopherol ◽  
Synthetic Vitamin ◽  
Male Subjects ◽  
Natural And Synthetic

There are several reports in the literature on the relative bioavailabilities of RRR (natural) vs. all-rac (synthetic) forms of vitamin E in humans and animal models but none on the bioavailability of alpha-tocopherol in mixed vitamin E formulations. In the present study we examined the bioavailability of alpha-tocopherol in a typical commercially available product containing mixed tocopherols. We also tested a formulation containing all-rac-alpha-tocopherol with mixed tocopherols for purposes of comparison along with straight RRR-and all-rac-alpha-tocopheryl acetate as reference products. Normal male subjects were given one of the four formulations of vitamin E (800 IU per day in softgel capsule form for 10 days): 1. All-rac-alpha-tocopheryl acetate, 2. RRR-alpha-tocopheryl acetate, 3. RRR-alpha-tocopherol with mixed tocopherols, and 4. all-rac-alpha-tocopherol with mixed tocopherols. Both serum alpha- and gamma-tocopherols were determined by HPLC at baseline, and at days 2, 4, 7 and 10. The values for alpha- at baseline and 10 days were 0.80, 0.80, 0.80 & 0.79 mg/dl and 1.67, 1.72, 1.76 & 1.62 mg/dl. The values for gamma- were 0.28, 0.29, 0.30 & 0.29 mg/dl and 0.11, 0.08, 0.10 & 0.10 mg/dl. Thus the data show that a) the bioavailability of RRR-and all-rac-alpha-tocopherols is not affected by other tocopherols, and b) both RRR-and all-rac-alpha-tocopherol (free or esterified) significantly suppress the serum gamma tocopherol to the same extent. Furthermore, since there was no difference in the serum values of alpha-tocopherol between RRR-and all-rac-vitamin E given the same dose as IUs, the data also support the currently accepted ratio of 1.36 for the biopotency of RRR- vs. all-rac-alpha-tocopheryl acetate.

scholarly journals Induction of Transplantable Tumors by Repeated Subcutaneous Injections of Natural and Synthetic Vitamin E in Mice and Rats

1991 ◽  
Vol 82 (5) ◽  
pp. 511-517 ◽  
Author(s):  
Yumiko Nitta ◽  
Kenji Kamiya ◽  
Masanori Tanimoto ◽  
Seiji Sadamoto ◽  
Ohtsura Niwa ◽  
...  
Keyword(s):  
Vitamin E ◽  
Subcutaneous Injections ◽  
Synthetic Vitamin ◽  
Transplantable Tumors ◽  
Natural And Synthetic

Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes

2010 ◽  
Vol 495 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Sung Nim Han ◽  
Eunice Pang ◽  
Jean-Marc Zingg ◽  
Simin Nikbin Meydani ◽  
Mohsen Meydani ◽  
...  
Keyword(s):  
Vitamin E ◽  
T Lymphocytes ◽  
Gene Transcription ◽  
Differential Effects ◽  
Synthetic Vitamin ◽  
Natural And Synthetic

scholarly journals Infants discriminate between natural and synthetic vitamin E

2003 ◽  
Vol 77 (4) ◽  
pp. 899-906 ◽  
Author(s):  
William L Stone ◽  
Irene LeClair ◽  
Terry Ponder ◽  
Geraldine Baggs ◽  
Bridget Barrett Reis
Keyword(s):  
Vitamin E ◽  
Synthetic Vitamin ◽  
Natural And Synthetic

scholarly journals Anticancer actions of natural and synthetic vitamin E forms: RRR-α-tocopherol blocks the anticancer actions of γ-tocopherol

2009 ◽  
Vol 53 (12) ◽  
pp. 1573-1581 ◽  
Author(s):  
Weiping Yu ◽  
Li Jia ◽  
Sook-Kyung Park ◽  
Jing Li ◽  
Archana Gopalan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Synthetic Vitamin ◽  
Natural And Synthetic

1120: Citrate and Vitamin E Blunt the SWL-Induced Free Radical Surge in an In-Vitro MDCK Cell Culture Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 295-295
Author(s):  
Fernando C. Delvecchio ◽  
Ricardo M. Brizuela ◽  
Karen J. Byer ◽  
W. Patrick Springhart ◽  
Saeed R. Khan ◽  
...  
Keyword(s):  
Cell Culture ◽  
Free Radical ◽  
Vitamin E ◽  
Mdck Cell ◽  
Cell Culture Model ◽  
Culture Model
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