Green alga Enteromorpha prolifera oligosaccharide ameliorates ageing and hyperglycemia through gut‐brain axis in age‐matched diabetic mice

2021 ◽  
pp. 2100564
Author(s):  
Yuezhen Ouyang ◽  
Dan Liu ◽  
Lizhu Zhang ◽  
Xiaoqing Li ◽  
Xinhua Chen ◽  
...  
2021 ◽  
pp. 112630
Author(s):  
Xiaoqing Li ◽  
Xiaoxiang Gao ◽  
Hui Zhang ◽  
Yuanyuan Liu ◽  
Md Moklesur Rahman Sarker ◽  
...  

2018 ◽  
Vol 20 (1) ◽  
pp. 25 ◽  
Author(s):  
Guopeng Lin ◽  
Xiaoyan Liu ◽  
Xin Yan ◽  
Dan Liu ◽  
Chengfeng Yang ◽  
...  

Effects of green macroalgae 55% ethanolic extract Enteromorpha prolifera through an ultrafiltration membrane of 3 kDa (EPE3k) on antidiabetic activity, gut microbiota, and regulation mechanism were investigated in high-fat/high-sucrose diet and streptozocin-induced diabetic mice. The structural characterizations of its major compounds in EPE3k were determined by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry. Furthermore, the intestinal microflora modulation in diabetic mice was also investigated with high-throughput 16S rRNA gene sequencing. The proposed presence of polyphenols in EPE3k was confirmed. EPE3k could significantly decrease the fasting blood glucose and improve fasting glucose tolerance. The hypoglycemic effect of EPE3k was via activation of phosphatidylinositol 3-kinase and suppression of c-Jun N-terminal kinase in liver. EPE3k treatment significantly increased the relative abundance of Akkermansia and decreased the proportion of Alistipes and Turicibacter. The above results indicated that EPE3k could be provided as a new potential therapy for the treatment of type 2 diabetic mellitus.


2003 ◽  
Vol 415 (2) ◽  
pp. 245-250 ◽  
Author(s):  
Andrea L Ambrosio ◽  
Libia Sanz ◽  
Eduardo I Sánchez ◽  
Carlota Wolfenstein-Todel ◽  
Juan J Calvete

1986 ◽  
Vol 157 (3) ◽  
pp. 502-506
Author(s):  
Richard J. SIMPSON ◽  
Robert L. MORITZ ◽  
Edouard C. NICE ◽  
Boris GREGO ◽  
Fuminori YOSHIZAKI ◽  
...  

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